ID   CUEA_CONAX              Reviewed;          17 AA.
AC   P0DOZ9;
DT   12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Conotoxin Asi14a {ECO:0000303|PubMed:27801785};
OS   Conus asiaticus (Cone snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Phasmoconus.
OX   NCBI_TaxID=1945508;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT GLY-17, SUBCELLULAR LOCATION, MASS
RP   SPECTROMETRY, SYNTHESIS, AND FUNCTION.
RC   TISSUE=Venom;
RX   PubMed=27801785; DOI=10.3390/md14110199;
RA   Lebbe E.K., Ghequire M.G., Peigneur S., Mille B.G., Devi P.,
RA   Ravichandran S., Waelkens E., D'Souza L., De Mot R., Tytgat J.;
RT   "Novel conopeptides of largely unexplored indo Pacific Conus sp.";
RL   Mar. Drugs 14:199-216(2016).
CC   -!- FUNCTION: May have neurotoxic activities (Probable). Does not show any
CC       effect on voltage-gated potassium channels (10 uM of toxin tested), and
CC       on nicotinic acetylcholine receptors (5 uM of toxin tested)
CC       (PubMed:27801785). Does not show antibacterial activity on both Gram-
CC       negative and Gram-positive bacteria (PubMed:27801785).
CC       {ECO:0000269|PubMed:27801785, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27801785}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:27801785}.
CC   -!- DOMAIN: The cysteine framework is XIV (C-C-C-C). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds. {ECO:0000305|PubMed:27801785}.
CC   -!- MASS SPECTROMETRY: Mass=1697.6; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:27801785};
CC   -!- MISCELLANEOUS: Does not show effect on Kv1.1, Kv1.2, Kv1.3, Kv1.4,
CC       Kv1.5, and Kv1.6 (PubMed:27801785). Does not show effect on muscular
CC       (alpha-1-beta-1-delta-epsilon) and neuronal alpha-7, alpha-4-beta-4,
CC       and alpha-3-beta-4 nAChRs (PubMed:27801785).
CC       {ECO:0000269|PubMed:27801785}.
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DR   AlphaFoldDB; P0DOZ9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Neurotoxin; Secreted;
KW   Toxin.
FT   PEPTIDE         1..17
FT                   /note="Conotoxin Asi14a"
FT                   /evidence="ECO:0000269|PubMed:27801785"
FT                   /id="PRO_0000439518"
FT   MOD_RES         17
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:27801785"
SQ   SEQUENCE   17 AA;  1701 MW;  9925C5D372394A91 CRC64;
     SCGYPCSHCG IPGCYPG