CUED1_HUMAN
ID CUED1_HUMAN Reviewed; 386 AA.
AC Q9NWM3; D3DTZ2; Q9NWD0;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=CUE domain-containing protein 1;
GN Name=CUEDC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Embryonic head, and Hepatoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP STRUCTURE BY NMR OF 34-96.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the CUE domain in the human CUE domain containing
RT protein 1 (CUEDC1).";
RL Submitted (SEP-2006) to the PDB data bank.
CC -!- INTERACTION:
CC Q9NWM3; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-5838167, EBI-11096309;
CC Q9NWM3; Q5S007: LRRK2; NbExp=2; IntAct=EBI-5838167, EBI-5323863;
CC Q9NWM3; O43639: NCK2; NbExp=3; IntAct=EBI-5838167, EBI-713635;
CC Q9NWM3; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-5838167, EBI-741158;
CC Q9NWM3; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-5838167, EBI-358489;
CC Q9NWM3; P62837: UBE2D2; NbExp=3; IntAct=EBI-5838167, EBI-347677;
CC Q9NWM3; Q96LR5: UBE2E2; NbExp=3; IntAct=EBI-5838167, EBI-2129763;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NWM3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NWM3-2; Sequence=VSP_010316;
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DR EMBL; AK000746; BAA91357.1; -; mRNA.
DR EMBL; AK000977; BAA91452.1; -; mRNA.
DR EMBL; CH471109; EAW94498.1; -; Genomic_DNA.
DR EMBL; CH471109; EAW94501.1; -; Genomic_DNA.
DR EMBL; BC056882; AAH56882.1; -; mRNA.
DR CCDS; CCDS11599.1; -. [Q9NWM3-1]
DR RefSeq; NP_001258804.1; NM_001271875.1. [Q9NWM3-1]
DR RefSeq; NP_001278954.1; NM_001292025.1. [Q9NWM3-1]
DR RefSeq; XP_006721963.1; XM_006721900.2.
DR PDB; 2DHY; NMR; -; A=37-90.
DR PDBsum; 2DHY; -.
DR AlphaFoldDB; Q9NWM3; -.
DR SMR; Q9NWM3; -.
DR BioGRID; 135642; 111.
DR IntAct; Q9NWM3; 34.
DR MINT; Q9NWM3; -.
DR STRING; 9606.ENSP00000462717; -.
DR iPTMnet; Q9NWM3; -.
DR PhosphoSitePlus; Q9NWM3; -.
DR BioMuta; CUEDC1; -.
DR DMDM; 47116934; -.
DR EPD; Q9NWM3; -.
DR jPOST; Q9NWM3; -.
DR MassIVE; Q9NWM3; -.
DR MaxQB; Q9NWM3; -.
DR PaxDb; Q9NWM3; -.
DR PeptideAtlas; Q9NWM3; -.
DR PRIDE; Q9NWM3; -.
DR ProteomicsDB; 82953; -. [Q9NWM3-1]
DR ProteomicsDB; 82954; -. [Q9NWM3-2]
DR Antibodypedia; 18339; 101 antibodies from 24 providers.
DR DNASU; 404093; -.
DR Ensembl; ENST00000360238.6; ENSP00000353373.2; ENSG00000180891.13. [Q9NWM3-1]
DR Ensembl; ENST00000407144.6; ENSP00000384712.2; ENSG00000180891.13. [Q9NWM3-1]
DR Ensembl; ENST00000577830.6; ENSP00000462717.1; ENSG00000180891.13. [Q9NWM3-1]
DR GeneID; 404093; -.
DR KEGG; hsa:404093; -.
DR MANE-Select; ENST00000577830.6; ENSP00000462717.1; NM_001271875.2; NP_001258804.1.
DR UCSC; uc002ivd.3; human. [Q9NWM3-1]
DR CTD; 404093; -.
DR DisGeNET; 404093; -.
DR GeneCards; CUEDC1; -.
DR HGNC; HGNC:31350; CUEDC1.
DR HPA; ENSG00000180891; Low tissue specificity.
DR neXtProt; NX_Q9NWM3; -.
DR OpenTargets; ENSG00000180891; -.
DR PharmGKB; PA134913154; -.
DR VEuPathDB; HostDB:ENSG00000180891; -.
DR eggNOG; KOG4588; Eukaryota.
DR GeneTree; ENSGT00390000006762; -.
DR HOGENOM; CLU_064865_0_0_1; -.
DR InParanoid; Q9NWM3; -.
DR OMA; TDFKTMF; -.
DR OrthoDB; 1485571at2759; -.
DR PhylomeDB; Q9NWM3; -.
DR TreeFam; TF324332; -.
DR PathwayCommons; Q9NWM3; -.
DR SignaLink; Q9NWM3; -.
DR BioGRID-ORCS; 404093; 30 hits in 1068 CRISPR screens.
DR ChiTaRS; CUEDC1; human.
DR EvolutionaryTrace; Q9NWM3; -.
DR GenomeRNAi; 404093; -.
DR Pharos; Q9NWM3; Tbio.
DR PRO; PR:Q9NWM3; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9NWM3; protein.
DR Bgee; ENSG00000180891; Expressed in apex of heart and 169 other tissues.
DR ExpressionAtlas; Q9NWM3; baseline and differential.
DR Genevisible; Q9NWM3; HS.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR CDD; cd14366; CUE_CUED1; 1.
DR InterPro; IPR003892; CUE.
DR InterPro; IPR040195; CUE_CUED1.
DR InterPro; IPR040192; CUEDC1.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR13467; PTHR13467; 1.
DR Pfam; PF02845; CUE; 1.
DR SMART; SM00546; CUE; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR PROSITE; PS51140; CUE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Reference proteome.
FT CHAIN 1..386
FT /note="CUE domain-containing protein 1"
FT /id="PRO_0000079559"
FT DOMAIN 46..89
FT /note="CUE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 233..260
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_010316"
FT VARIANT 169
FT /note="R -> H (in dbSNP:rs17762338)"
FT /id="VAR_050933"
FT VARIANT 205
FT /note="P -> S (in dbSNP:rs2304942)"
FT /id="VAR_021951"
FT VARIANT 316
FT /note="R -> Q (in dbSNP:rs34800498)"
FT /id="VAR_033765"
FT CONFLICT 47
FT /note="F -> L (in Ref. 1; BAA91452)"
FT /evidence="ECO:0000305"
FT HELIX 48..57
FT /evidence="ECO:0007829|PDB:2DHY"
FT STRAND 59..61
FT /evidence="ECO:0007829|PDB:2DHY"
FT HELIX 63..73
FT /evidence="ECO:0007829|PDB:2DHY"
FT HELIX 77..89
FT /evidence="ECO:0007829|PDB:2DHY"
SQ SEQUENCE 386 AA; 42258 MW; F5530FA47C267895 CRC64;
MTSLFRRSSS GSGGGGTAGA RGGGGGTAAP QELNNSRPAR QVRRLEFNQA MDDFKTMFPN
MDYDIIECVL RANSGAVDAT IDQLLQMNLE GGGSSGGVYE DSSDSEDSIP PEILERTLEP
DSSDEEPPPV YSPPAYHMHV FDRPYPLAPP TPPPRIDALG SGAPTSQRRY RNWNPPLLGN
LPDDFLRILP QQLDSIQGNA GGPKPGSGEG CPPAMAGPGP GDQESRWKQY LEDERIALFL
QNEEFMKELQ RNRDFLLALE RDRLKYESQK SKSSSVAVGN DFGFSSPVPG TGDANPAVSE
DALFRDKLKH MGKSTRRKLF ELARAFSEKT KMRKSKRKHL LKHQSLGAAA STANLLDDVE
GHACDEDFRG RRQEAPKVEE GLREGQ
