ID   CUED2_BOVIN             Reviewed;         283 AA.
AC   Q3ZBN4;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=CUE domain-containing protein 2;
GN   Name=CUEDC2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Controls PGR and ESR1 protein levels through their targeting
CC       for ubiquitination and subsequent proteasomal degradation.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PGR and ESR1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The CUE domain mediates interaction with PGR and ESR1.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CUEDC2 family. {ECO:0000305}.
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DR   EMBL; BC103201; AAI03202.1; -; mRNA.
DR   RefSeq; NP_001069205.1; NM_001075737.1.
DR   AlphaFoldDB; Q3ZBN4; -.
DR   STRING; 9913.ENSBTAP00000003250; -.
DR   PRIDE; Q3ZBN4; -.
DR   Ensembl; ENSBTAT00000003250; ENSBTAP00000003250; ENSBTAG00000002501.
DR   GeneID; 516091; -.
DR   KEGG; bta:516091; -.
DR   CTD; 79004; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002501; -.
DR   VGNC; VGNC:55945; CUEDC2.
DR   GeneTree; ENSGT00390000014513; -.
DR   InParanoid; Q3ZBN4; -.
DR   OMA; DDQKTHR; -.
DR   OrthoDB; 1410219at2759; -.
DR   Proteomes; UP000009136; Chromosome 26.
DR   Bgee; ENSBTAG00000002501; Expressed in uterine tube infundibulum and 105 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR   GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IEA:Ensembl.
DR   GO; GO:0010936; P:negative regulation of macrophage cytokine production; IEA:Ensembl.
DR   CDD; cd14367; CUE_CUED2; 1.
DR   InterPro; IPR003892; CUE.
DR   InterPro; IPR039805; CUE_CUED2.
DR   InterPro; IPR039784; CUEDC2.
DR   PANTHER; PTHR12493; PTHR12493; 1.
DR   PROSITE; PS51140; CUE; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome;
KW   Ubl conjugation pathway.
FT   CHAIN           1..283
FT                   /note="CUE domain-containing protein 2"
FT                   /id="PRO_0000282991"
FT   DOMAIN          141..184
FT                   /note="CUE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
FT   REGION          87..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..111
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         110
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H467"
SQ   SEQUENCE   283 AA;  31532 MW;  FAC6CAB96CA75313 CRC64;
     MELERIVSAA LLAFVQTHLP EADLSGLDDV IFSYVLGVLG DLGPSGPSEE NFDMEAFTEM
     MEAYVPGFAH IPRGTIGDMI QKLSGQLSGA RNKENVQPQS SEVQGQVSIS PEPLQRPEKL
     KEETMSSAGD TQDEAAGPEE ELLPGVDVLL EVFPTCSVEQ AQWVLAKARG DLEEAVQMLV
     EGKQGPPAWD GPNQDLPRRL RGPQKDELKS FILQKYMMVD SAEDQKIHRP MAPKEAPKKL
     IRYIDNQIVS TKGERFKDVR NPEAEEMKAT YINLKPARKY RFH