ID   CUED2_DANRE             Reviewed;         282 AA.
AC   Q6TLH3;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=CUE domain-containing protein 2;
GN   Name=cuedc2; ORFNames=zgc:92255;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in targeting proteins for ubiquitination and
CC       subsequent proteasomal degradation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CUEDC2 family. {ECO:0000305}.
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DR   EMBL; AY394932; AAQ94559.1; -; mRNA.
DR   EMBL; BC081633; AAH81633.1; -; mRNA.
DR   RefSeq; NP_001017994.1; NM_001017994.2.
DR   RefSeq; XP_005156839.1; XM_005156782.1.
DR   AlphaFoldDB; Q6TLH3; -.
DR   STRING; 7955.ENSDARP00000057527; -.
DR   PaxDb; Q6TLH3; -.
DR   Ensembl; ENSDART00000057528; ENSDARP00000057527; ENSDARG00000039365.
DR   Ensembl; ENSDART00000123482; ENSDARP00000107612; ENSDARG00000039365.
DR   GeneID; 334351; -.
DR   KEGG; dre:334351; -.
DR   CTD; 79004; -.
DR   ZFIN; ZDB-GENE-030131-6283; cuedc2.
DR   eggNOG; ENOG502RZII; Eukaryota.
DR   GeneTree; ENSGT00390000014513; -.
DR   HOGENOM; CLU_048031_0_0_1; -.
DR   InParanoid; Q6TLH3; -.
DR   OMA; DDQKTHR; -.
DR   OrthoDB; 1410219at2759; -.
DR   PhylomeDB; Q6TLH3; -.
DR   TreeFam; TF324328; -.
DR   PRO; PR:Q6TLH3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000039365; Expressed in early embryo and 28 other tissues.
DR   ExpressionAtlas; Q6TLH3; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd14367; CUE_CUED2; 1.
DR   InterPro; IPR039805; CUE_CUED2.
DR   InterPro; IPR039784; CUEDC2.
DR   PANTHER; PTHR12493; PTHR12493; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..282
FT                   /note="CUE domain-containing protein 2"
FT                   /id="PRO_0000282995"
FT   DOMAIN          140..183
FT                   /note="CUE"
SQ   SEQUENCE   282 AA;  31712 MW;  BF67DEBFF418354B CRC64;
     MDLQKIIHDA LYDFILSYIP HADLSTLDDV ILSYITGVLE DLGSQESVEE NFDVEVFVEM
     LEAYIPGFSD IDSVKVCEMM FNLAAKLTSA RDTESGEMKI EEGKFPLSES CDLSLGGSRE
     KTHNLTLQAE GATAQVSESS WDNQEQHLLE MFPKCSVTEA RSALSIAKGD MEEAVRLIIE
     GDVQLKCPPS LSANQGKTVS AEVDQKLKAS ILEKYMLVDD EEDKKVHRPV TPKDAPKKMV
     RYHGSQVVTT KGERYHLVKK EEPEDMKKTY VSLKPARKYR FH