CUED2_MOUSE
ID CUED2_MOUSE Reviewed; 284 AA.
AC Q9CXX9; Q99LC1;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=CUE domain-containing protein 2;
GN Name=Cuedc2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung tumor;
RA Matsumoto K., Abiko S., Ariga H.;
RT "Nucleotide sequence of mouse CUEDC2 mRNA.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Controls PGR and ESR1 protein levels through their targeting
CC for ubiquitination and subsequent proteasomal degradation.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PGR and ESR1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- DOMAIN: The CUE domain mediates interaction with PGR and ESR1.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CUEDC2 family. {ECO:0000305}.
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DR EMBL; AB232359; BAE19943.1; -; mRNA.
DR EMBL; AK013884; BAB29035.1; -; mRNA.
DR EMBL; BC003442; AAH03442.1; -; mRNA.
DR CCDS; CCDS29876.1; -.
DR RefSeq; NP_001157762.1; NM_001164290.1.
DR RefSeq; NP_001157763.1; NM_001164291.1.
DR RefSeq; NP_001157764.1; NM_001164292.1.
DR RefSeq; NP_001157765.1; NM_001164293.1.
DR RefSeq; NP_001157766.1; NM_001164294.1.
DR RefSeq; NP_001157767.1; NM_001164295.1.
DR RefSeq; NP_077154.2; NM_024192.2.
DR RefSeq; XP_006527338.1; XM_006527275.3.
DR RefSeq; XP_006527339.1; XM_006527276.2.
DR RefSeq; XP_006527340.1; XM_006527277.3.
DR RefSeq; XP_006527341.1; XM_006527278.2.
DR RefSeq; XP_011245619.1; XM_011247317.1.
DR RefSeq; XP_011245620.1; XM_011247318.1.
DR RefSeq; XP_011245621.1; XM_011247319.1.
DR AlphaFoldDB; Q9CXX9; -.
DR BioGRID; 211950; 3.
DR STRING; 10090.ENSMUSP00000129589; -.
DR iPTMnet; Q9CXX9; -.
DR PhosphoSitePlus; Q9CXX9; -.
DR EPD; Q9CXX9; -.
DR MaxQB; Q9CXX9; -.
DR PaxDb; Q9CXX9; -.
DR PeptideAtlas; Q9CXX9; -.
DR PRIDE; Q9CXX9; -.
DR ProteomicsDB; 279234; -.
DR Antibodypedia; 31442; 316 antibodies from 36 providers.
DR Ensembl; ENSMUST00000051234; ENSMUSP00000053469; ENSMUSG00000036748.
DR Ensembl; ENSMUST00000167861; ENSMUSP00000129589; ENSMUSG00000036748.
DR Ensembl; ENSMUST00000235485; ENSMUSP00000158425; ENSMUSG00000036748.
DR Ensembl; ENSMUST00000236046; ENSMUSP00000157580; ENSMUSG00000036748.
DR Ensembl; ENSMUST00000236061; ENSMUSP00000157840; ENSMUSG00000036748.
DR GeneID; 67116; -.
DR KEGG; mmu:67116; -.
DR UCSC; uc008htg.2; mouse.
DR CTD; 79004; -.
DR MGI; MGI:1914366; Cuedc2.
DR VEuPathDB; HostDB:ENSMUSG00000036748; -.
DR eggNOG; ENOG502RZII; Eukaryota.
DR GeneTree; ENSGT00390000014513; -.
DR HOGENOM; CLU_048031_0_0_1; -.
DR InParanoid; Q9CXX9; -.
DR OMA; DDQKTHR; -.
DR OrthoDB; 1410219at2759; -.
DR PhylomeDB; Q9CXX9; -.
DR TreeFam; TF324328; -.
DR BioGRID-ORCS; 67116; 5 hits in 73 CRISPR screens.
DR ChiTaRS; Cuedc2; mouse.
DR PRO; PR:Q9CXX9; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9CXX9; protein.
DR Bgee; ENSMUSG00000036748; Expressed in embryonic brain and 262 other tissues.
DR ExpressionAtlas; Q9CXX9; baseline and differential.
DR Genevisible; Q9CXX9; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0031965; C:nuclear membrane; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IMP:MGI.
DR GO; GO:0010936; P:negative regulation of macrophage cytokine production; IMP:MGI.
DR CDD; cd14367; CUE_CUED2; 1.
DR InterPro; IPR003892; CUE.
DR InterPro; IPR039805; CUE_CUED2.
DR InterPro; IPR039784; CUEDC2.
DR PANTHER; PTHR12493; PTHR12493; 1.
DR PROSITE; PS51140; CUE; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..284
FT /note="CUE domain-containing protein 2"
FT /id="PRO_0000282993"
FT DOMAIN 141..184
FT /note="CUE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
FT REGION 183..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 13
FT /note="T -> A (in Ref. 3; AAH03442)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="G -> R (in Ref. 3; AAH03442)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 284 AA; 31852 MW; DFFAB8D0261F03C2 CRC64;
MELERIVGSA LLTFVQAHLP EADLSGLDEV IFSYVLGVLE DLGPSGPSEE NFDMEAFTEM
MEAYVPGFAH IPRGIIGDMM QKLSVQLSDA RNKENLHPQS SCVQGQVPIF PETPRQAEKL
EEESRPPAAP GNTLDEAAAA EELPGVDVLL EVFPTCSMEQ AQWVLAKARG DLEEAVHMLV
EGKEEGPPGW DGPSQDLPRR LRGPQKDDLK SFILQKYMMV DRAEDQKTHR PMAPKEAPKK
LIRYIDNQVV STKGERFKDV RNPEAEEMKA TYINLKPARK YRFH
