ID   CUED2_RAT               Reviewed;         267 AA.
AC   A1L131;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=CUE domain-containing protein 2;
GN   Name=Cuedc2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Controls PGR and ESR1 protein levels through their targeting
CC       for ubiquitination and subsequent proteasomal degradation.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PGR and ESR1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The CUE domain mediates interaction with PGR and ESR1.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CUEDC2 family. {ECO:0000305}.
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DR   EMBL; BC127518; AAI27519.1; -; mRNA.
DR   RefSeq; NP_001073355.1; NM_001079886.1.
DR   RefSeq; XP_006231527.1; XM_006231465.3.
DR   RefSeq; XP_006231528.1; XM_006231466.2.
DR   RefSeq; XP_008758631.2; XM_008760409.2.
DR   AlphaFoldDB; A1L131; -.
DR   STRING; 10116.ENSRNOP00000026609; -.
DR   PaxDb; A1L131; -.
DR   PeptideAtlas; A1L131; -.
DR   GeneID; 294009; -.
DR   KEGG; rno:294009; -.
DR   CTD; 79004; -.
DR   RGD; 1308096; Cuedc2.
DR   VEuPathDB; HostDB:ENSRNOG00000019574; -.
DR   eggNOG; ENOG502RZII; Eukaryota.
DR   HOGENOM; CLU_048031_0_0_1; -.
DR   InParanoid; A1L131; -.
DR   OMA; DDQKTHR; -.
DR   OrthoDB; 1410219at2759; -.
DR   PhylomeDB; A1L131; -.
DR   PRO; PR:A1L131; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000019574; Expressed in thymus and 19 other tissues.
DR   Genevisible; A1L131; RN.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR   GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; ISO:RGD.
DR   GO; GO:0010936; P:negative regulation of macrophage cytokine production; ISO:RGD.
DR   CDD; cd14367; CUE_CUED2; 1.
DR   InterPro; IPR003892; CUE.
DR   InterPro; IPR039805; CUE_CUED2.
DR   InterPro; IPR039784; CUEDC2.
DR   PANTHER; PTHR12493; PTHR12493; 1.
DR   PROSITE; PS51140; CUE; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..267
FT                   /note="CUE domain-containing protein 2"
FT                   /id="PRO_0000282994"
FT   DOMAIN          124..167
FT                   /note="CUE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
FT   REGION          90..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..107
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   267 AA;  30282 MW;  8C4C0AD987723BFD CRC64;
     MELERIVSSA LFAFVQTHLP EADLSGLDEV IFSYVLGVLE DLGPSGPSEE NFDMEAFIEM
     MEAYVPGFAH IHRGIIEDMV QTLSVQLSSA RNKETLRRPE KLKEESRPPA ATGNTQDEAA
     AAEEEQPGVD VLLEVFPTCS MEQAQWVLAK ARGNLEEAVQ MLIEGKEEGP PGWGGPNQDL
     PRRLRGPRKE ELKSFILQKY MMVDRAEDQK THRPMAPKEA PKKLIRYIDN QVVSTKGERF
     KDVRNPETEE MKATYINLKP ARKYRFH