ID   CUEDB_CONCL             Reviewed;          68 AA.
AC   D2Y101;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Conotoxin Cal14.13b {ECO:0000305};
DE   AltName: Full=Conotoxin Cal14.1b {ECO:0000303|PubMed:21172372};
DE   Flags: Precursor;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT MET-66.
RC   TISSUE=Venom duct;
RX   PubMed=21172372; DOI=10.1016/j.toxicon.2010.12.008;
RA   Elliger C.A., Richmond T.A., Lebaric Z.N., Pierce N.T., Sweedler J.V.,
RA   Gilly W.F.;
RT   "Diversity of conotoxin types from Conus californicus reflects a diversity
RT   of prey types and a novel evolutionary history.";
RL   Toxicon 57:311-322(2011).
CC   -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC       channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21172372}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:21172372}.
CC   -!- DOMAIN: The cysteine framework is XIV (C-C-C-C).
CC   -!- PTM: Contains 2 disulfide bonds. {ECO:0000250}.
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DR   EMBL; GU289669; ADB28953.1; -; mRNA.
DR   AlphaFoldDB; D2Y101; -.
DR   SMR; D2Y101; -.
DR   ConoServer; 3978; Cal14.13b precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..68
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000566275"
FT   PEPTIDE         40..66
FT                   /note="Conotoxin Cal14.13b"
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000566276"
FT   MOD_RES         66
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000305|PubMed:21172372"
SQ   SEQUENCE   68 AA;  7527 MW;  C0189FD281BC2633 CRC64;
     MKLCVVIVLL MLAMPFNGGE ASRFFNQHAR SQRSGMKTRG IWCDPPCPEG ETCRGGECSD
     EFNGDMGR