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CUER_ECO57
ID   CUER_ECO57              Reviewed;         135 AA.
AC   Q8XD09; Q8KY47;
DT   03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=HTH-type transcriptional regulator CueR;
DE   AltName: Full=Copper efflux regulator;
DE   AltName: Full=Copper export regulator;
GN   Name=cueR; OrderedLocusNames=Z0636, ECs0545;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-135.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=12147073; DOI=10.1046/j.1365-2672.2002.01684.x;
RA   Perelle S., Fach P., Dilasser F., Grout J.;
RT   "A PCR test for detecting Escherichia coli O157:H7 based on the
RT   identification of the small inserted locus (SILO157).";
RL   J. Appl. Microbiol. 93:250-260(2002).
CC   -!- FUNCTION: Regulates the transcription of the copA and cueO genes. It
CC       detects cytoplasmic copper stress and activates transcription in
CC       response to increasing copper concentrations (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- DOMAIN: It contains a N-terminal DNA binding region and a C-terminal
CC       metal binding region. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG54841.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005174; AAG54841.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB33968.1; -; Genomic_DNA.
DR   EMBL; AF288452; AAN02438.1; -; Genomic_DNA.
DR   PIR; A90697; A90697.
DR   PIR; E85547; E85547.
DR   RefSeq; NP_308572.1; NC_002695.1.
DR   RefSeq; WP_001026752.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8XD09; -.
DR   SMR; Q8XD09; -.
DR   STRING; 155864.EDL933_0569; -.
DR   EnsemblBacteria; AAG54841; AAG54841; Z0636.
DR   EnsemblBacteria; BAB33968; BAB33968; ECs_0545.
DR   GeneID; 915192; -.
DR   KEGG; ece:Z0636; -.
DR   KEGG; ecs:ECs_0545; -.
DR   PATRIC; fig|386585.9.peg.652; -.
DR   eggNOG; COG0789; Bacteria.
DR   HOGENOM; CLU_060077_2_0_6; -.
DR   OMA; FNDPERH; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01108; HTH_CueR; 1.
DR   InterPro; IPR011789; CueR.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   Pfam; PF13411; MerR_1; 1.
DR   PRINTS; PR00040; HTHMERR.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR02044; CueR; 1.
DR   PROSITE; PS00552; HTH_MERR_1; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Copper; Cytoplasm; DNA-binding; Metal-binding;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..135
FT                   /note="HTH-type transcriptional regulator CueR"
FT                   /id="PRO_0000098113"
FT   DOMAIN          1..69
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   BINDING         112
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /evidence="ECO:0000250"
FT   BINDING         120
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   135 AA;  15234 MW;  ADA0D919E3140862 CRC64;
     MNISDVAKIT GLTSKAIRFY EEKGLVTPPM RSENGYRTYT QQHLNELTLL RQARQVGFNL
     EESGELVNLF NDPQRHSADV KRRTLEKVAE IERHIEELQS MRNQLLALAN ACPGDDSADC
     PIIENLSGCC HHRAG
 
 
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