CUER_SALTI
ID CUER_SALTI Reviewed; 138 AA.
AC Q8Z8S3;
DT 03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=HTH-type transcriptional regulator CueR;
DE AltName: Full=Copper efflux regulator;
DE AltName: Full=Copper export regulator;
GN Name=cueR; OrderedLocusNames=STY0545, t2361;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Regulates the transcription of the copA and cueO genes. It
CC detects cytoplasmic copper stress and activates transcription in
CC response to increasing copper concentrations (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- DOMAIN: It contains a N-terminal DNA binding region and a C-terminal
CC metal binding region. {ECO:0000250}.
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DR EMBL; AL513382; CAD04984.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO69953.1; -; Genomic_DNA.
DR RefSeq; NP_455094.1; NC_003198.1.
DR RefSeq; WP_001026762.1; NZ_WSUR01000008.1.
DR AlphaFoldDB; Q8Z8S3; -.
DR SMR; Q8Z8S3; -.
DR STRING; 220341.16501769; -.
DR EnsemblBacteria; AAO69953; AAO69953; t2361.
DR KEGG; stt:t2361; -.
DR KEGG; sty:STY0545; -.
DR PATRIC; fig|220341.7.peg.548; -.
DR eggNOG; COG0789; Bacteria.
DR HOGENOM; CLU_060077_2_0_6; -.
DR OMA; FNDPERH; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd01108; HTH_CueR; 1.
DR InterPro; IPR011789; CueR.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR Pfam; PF13411; MerR_1; 1.
DR PRINTS; PR00040; HTHMERR.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
DR TIGRFAMs; TIGR02044; CueR; 1.
DR PROSITE; PS00552; HTH_MERR_1; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 3: Inferred from homology;
KW Activator; Copper; Cytoplasm; DNA-binding; Metal-binding; Transcription;
KW Transcription regulation.
FT CHAIN 1..138
FT /note="HTH-type transcriptional regulator CueR"
FT /id="PRO_0000098114"
FT DOMAIN 1..69
FT /note="HTH merR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT DNA_BIND 4..23
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT BINDING 112
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /evidence="ECO:0000250"
FT BINDING 120
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /evidence="ECO:0000250"
SQ SEQUENCE 138 AA; 15682 MW; 3A7691C23EA6D940 CRC64;
MNISDVAKKT GLTSKAIRFY EEKGLVTPPL RSENGYRTYT QKHLNELTLL RQARQVGFNL
EECGELVNLF NDPRRHSADV KKRTLEKVAE IERHISELQS MRDQLLAMAE SCPGDDSADC
PIIDNLSGCC HHKAQKLR
