ID   CUER_VIBCH              Reviewed;         139 AA.
AC   P0C6D2; Q9EVT1; Q9KTC8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=HTH-type transcriptional regulator CueR;
DE   AltName: Full=Copper efflux regulator;
DE   AltName: Full=Copper export regulator;
GN   Name=cueR; Synonyms=vvgR; OrderedLocusNames=VC_0974;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Regulates the transcription of the copA and cueO genes. It
CC       detects cytoplasmic copper stress and activates transcription in
CC       response to increasing copper concentrations (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- DOMAIN: It contains a N-terminal DNA binding region and a C-terminal
CC       metal binding region. {ECO:0000250}.
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DR   EMBL; AE003852; AAF94136.1; -; Genomic_DNA.
DR   PIR; D82256; D82256.
DR   RefSeq; NP_230621.1; NC_002505.1.
DR   RefSeq; WP_001027396.1; NZ_LT906614.1.
DR   AlphaFoldDB; P0C6D2; -.
DR   SMR; P0C6D2; -.
DR   STRING; 243277.VC_0974; -.
DR   DNASU; 2614227; -.
DR   EnsemblBacteria; AAF94136; AAF94136; VC_0974.
DR   GeneID; 57739662; -.
DR   KEGG; vch:VC_0974; -.
DR   PATRIC; fig|243277.26.peg.927; -.
DR   eggNOG; COG0789; Bacteria.
DR   HOGENOM; CLU_060077_2_0_6; -.
DR   OMA; HQSCASA; -.
DR   BioCyc; VCHO:VC0974-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01108; HTH_CueR; 1.
DR   InterPro; IPR011789; CueR.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   Pfam; PF13411; MerR_1; 1.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR02044; CueR; 1.
DR   PROSITE; PS00552; HTH_MERR_1; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Copper; Cytoplasm; DNA-binding; Metal-binding;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..139
FT                   /note="HTH-type transcriptional regulator CueR"
FT                   /id="PRO_0000098117"
FT   DOMAIN          1..69
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   BINDING         112
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /evidence="ECO:0000250"
FT   BINDING         120
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   139 AA;  15693 MW;  84CEDED9D411B012 CRC64;
     MNISQIAKLT SLTAKSIRLY EEKGLIIPPL RSESGYRTYT QQHVDDLLLI ARCRRVGFSL
     DECKAMLTLA NDPNRTSAAV RARAQEKWQE ISRKLSELTM IKQQLEEWIA SCPGDQGSDC
     PIIEQLKGHC CSNNKTKTP