CUER_YERPE
ID CUER_YERPE Reviewed; 139 AA.
AC Q8ZCA8; Q0WCI3;
DT 03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=HTH-type transcriptional regulator CueR;
DE AltName: Full=Copper efflux regulator;
DE AltName: Full=Copper export regulator;
GN Name=cueR; OrderedLocusNames=YPO3085, y1094, YP_0839;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Regulates the transcription of the copA and cueO genes. It
CC detects cytoplasmic copper stress and activates transcription in
CC response to increasing copper concentrations (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- DOMAIN: It contains a N-terminal DNA binding region and a C-terminal
CC metal binding region. {ECO:0000250}.
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DR EMBL; AL590842; CAL21687.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84672.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS61098.1; -; Genomic_DNA.
DR PIR; AD0375; AD0375.
DR RefSeq; WP_002208578.1; NZ_WUCM01000009.1.
DR RefSeq; YP_002348005.1; NC_003143.1.
DR AlphaFoldDB; Q8ZCA8; -.
DR SMR; Q8ZCA8; -.
DR STRING; 214092.YPO3085; -.
DR PaxDb; Q8ZCA8; -.
DR DNASU; 1146041; -.
DR EnsemblBacteria; AAM84672; AAM84672; y1094.
DR EnsemblBacteria; AAS61098; AAS61098; YP_0839.
DR GeneID; 66842553; -.
DR KEGG; ype:YPO3085; -.
DR KEGG; ypk:y1094; -.
DR KEGG; ypm:YP_0839; -.
DR PATRIC; fig|1028802.3.peg.327; -.
DR eggNOG; COG0789; Bacteria.
DR HOGENOM; CLU_060077_2_0_6; -.
DR OMA; FNDPERH; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd01108; HTH_CueR; 1.
DR InterPro; IPR011789; CueR.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR Pfam; PF13411; MerR_1; 1.
DR PRINTS; PR00040; HTHMERR.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
DR TIGRFAMs; TIGR02044; CueR; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 3: Inferred from homology;
KW Activator; Copper; Cytoplasm; DNA-binding; Metal-binding;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..139
FT /note="HTH-type transcriptional regulator CueR"
FT /id="PRO_0000098118"
FT DOMAIN 1..69
FT /note="HTH merR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT DNA_BIND 4..23
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT BINDING 112
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /evidence="ECO:0000250"
FT BINDING 120
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /evidence="ECO:0000250"
SQ SEQUENCE 139 AA; 15463 MW; DD12717B83E3C6C7 CRC64;
MNISDVAKKT GLTSKAIRFY EEKKLVTPPV RTDNGYRSYT AKHIEELTLL RQARQVGFTL
DECRELLALF HNPARHSADV KAATLLKVAE IEQHINDLNQ MRMRLLALAE ECPGDEGADC
PIINSLAGCC HSSSSLPLK
