CUE_ANOGA
ID CUE_ANOGA Reviewed; 704 AA.
AC Q7QIQ6;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 4.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Protein cueball {ECO:0000250|UniProtKB:Q95RU0};
DE Flags: Precursor;
GN Name=cue {ECO:0000250|UniProtKB:Q95RU0}; ORFNames=AGAP007023;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1] {ECO:0000312|EMBL:EAA04702.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Has a role in spermatogenesis and oogenesis.
CC {ECO:0000250|UniProtKB:Q95RU0}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cueball family. {ECO:0000305}.
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DR EMBL; AAAB01008807; EAA04702.4; -; Genomic_DNA.
DR RefSeq; XP_308749.4; XM_308749.4.
DR AlphaFoldDB; Q7QIQ6; -.
DR STRING; 7165.AGAP007023-PA; -.
DR PaxDb; Q7QIQ6; -.
DR GeneID; 1270082; -.
DR KEGG; aga:AgaP_AGAP007023; -.
DR CTD; 1270082; -.
DR VEuPathDB; VectorBase:AGAP007023; -.
DR eggNOG; KOG1215; Eukaryota.
DR HOGENOM; CLU_026602_0_0_1; -.
DR InParanoid; Q7QIQ6; -.
DR OMA; KLYWTNS; -.
DR OrthoDB; 520442at2759; -.
DR PhylomeDB; Q7QIQ6; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.30; -; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00135; LY; 5.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 3.
PE 3: Inferred from homology;
KW Cell membrane; Differentiation; Disulfide bond; EGF-like domain;
KW Glycoprotein; Membrane; Oogenesis; Reference proteome; Repeat; Signal;
KW Spermatogenesis; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..704
FT /note="Protein cueball"
FT /evidence="ECO:0000255"
FT /id="PRO_0000386567"
FT TOPO_DOM 27..594
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 595..615
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 616..704
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 69..119
FT /note="LDL-receptor class B 1"
FT /evidence="ECO:0000255"
FT REPEAT 120..166
FT /note="LDL-receptor class B 2"
FT /evidence="ECO:0000255"
FT REPEAT 199..242
FT /note="LDL-receptor class B 3"
FT /evidence="ECO:0000255"
FT REPEAT 243..288
FT /note="LDL-receptor class B 4"
FT /evidence="ECO:0000255"
FT DOMAIN 363..397
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 432..478
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 514..551
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT CARBOHYD 152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 219
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 375
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 450
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 532
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 592
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 372..385
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 387..396
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 436..446
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 440..465
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 467..477
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 518..528
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 522..539
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 541..550
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 704 AA; 79143 MW; 4E59FE1888ED20B8 CRC64;
MKSPCRAAAG WLVLLLSSCC LGYVIATEWA AAVTTDNGIL FFDSNWRKIS SAAHQYSRIS
AFAYDEVLGK LYFADLDHPE YRLFALDYDD TDELHKVTKL LPKSAQTAYI SGMAFDHLER
RLYWTEKGTR SVYYVAIDEL LSSTRSAAAA ANGTAAAAAT AVEATTSAPP PSSSSPVQLV
ATVQPDHELA GLAIDECRRH LYWTNCYPKT SNIVRAAMNG TVLNVHEEQV YLPKGITVDH
YRNRLYWVEK KYGRRYTIES ADLEVNDQRT LQTGLDRLPA DIAVKNDYIY WTDQENNEIY
EMSKEPNAPS RTVYRGEHPS AVILRANLLL EHQRNNPDCR SVVDRILENM QNSKPASVLQ
QETQQQGQLT VCLNNGTVNH HTNTCLCQPA FGGKLCEIDL CNNYCAQGSC RIGRDNRPRC
DCDRRYEGDR CDRNRCDGFC LNGGRCQFSN GTAGRTEEEM GDRTCLCEST GYSGARCENP
ICGTDYCYNG ECYVEEGKRP KCRCKAGYRG ERCEEYSCNN YCLNGGHCTL GNETTVPECE
CGEEFAGQRC EIAVRLCSTY NEDPQWQQYC LGISKTLPLM EPKVTYCKES FNRTVVYTSL
CFTVSFALLL AVVLVVSRMM KPPRPRITKK MVVTPMTSRP PTTQCEITIE NCCNMNVCET
PCFDTKLLKK SKKEDKQFLL EDIEDVGGSY RKLPNCGDGT AERK
