CUE_DROER
ID CUE_DROER Reviewed; 644 AA.
AC B3NBB6;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Protein cueball {ECO:0000250|UniProtKB:Q95RU0};
DE Flags: Precursor;
GN Name=cue {ECO:0000250|UniProtKB:Q95RU0}; ORFNames=GG14595;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220;
RN [1] {ECO:0000312|EMBL:EDV50169.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14021-0224.01 {ECO:0000312|EMBL:EDV50169.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Has a role in spermatogenesis and oogenesis.
CC {ECO:0000250|UniProtKB:Q95RU0}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cueball family. {ECO:0000305}.
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DR EMBL; CH954178; EDV50169.1; -; Genomic_DNA.
DR RefSeq; XP_001971143.1; XM_001971107.2.
DR AlphaFoldDB; B3NBB6; -.
DR SMR; B3NBB6; -.
DR STRING; 7220.FBpp0133141; -.
DR EnsemblMetazoa; FBtr0134649; FBpp0133141; FBgn0106851.
DR GeneID; 6545668; -.
DR KEGG; der:6545668; -.
DR eggNOG; KOG1215; Eukaryota.
DR HOGENOM; CLU_026602_0_0_1; -.
DR OMA; KLYWTNS; -.
DR OrthoDB; 520442at2759; -.
DR PhylomeDB; B3NBB6; -.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.30; -; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR Pfam; PF00058; Ldl_recept_b; 2.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00135; LY; 4.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS51120; LDLRB; 3.
PE 3: Inferred from homology;
KW Cell membrane; Differentiation; Disulfide bond; EGF-like domain;
KW Glycoprotein; Membrane; Oogenesis; Repeat; Signal; Spermatogenesis;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..644
FT /note="Protein cueball"
FT /evidence="ECO:0000255"
FT /id="PRO_0000386570"
FT TOPO_DOM 27..531
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 532..552
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 553..644
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 121..166
FT /note="LDL-receptor class B 1"
FT /evidence="ECO:0000255"
FT REPEAT 167..211
FT /note="LDL-receptor class B 2"
FT /evidence="ECO:0000255"
FT REPEAT 212..257
FT /note="LDL-receptor class B 3"
FT /evidence="ECO:0000255"
FT DOMAIN 398..430
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 433..471
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 196
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 313
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 473
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 508
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 402..411
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 406..421
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 437..447
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 441..459
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 461..470
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 644 AA; 72658 MW; A8260D579E5FEA5F CRC64;
MIRIRFGMDV LLVLLLATCL LSPAHGTPLE WDFAVTLRTK IQFMDSSWQT IATAAHEFDE
LSAITFDESE ELIYFNDMRH QNGSIFSLKR DLVAANHVVE QRIARTGNES VGGLAYDPLT
MNLFWSDIEQ RKIFFAPIDG SAAPKVLVDL SAEGGRPDGV AVDVCRRKLY WTNSNVTHPT
VERINLDGNN RTVIINSTID MPRGIVVDQL SDRLFWIDDL KGVFFAIESS KLDGSDRLVV
LKDKHHEPLN LAVTNDAIYW TDRTTRSVWS HPKVPVIRVT TTSKPVEEDS TDSTDFKDPE
PVNEDCPLVR VANLSEEVRG IVVRTGFYQR LQKDHHCASI VRKVKERVDA QNTKFEVRSL
QDQKMKILQD ERCMNHGEYK PATDLCICPT GFKGSRCEIR ECHNYCVHGT CQMSESAYPK
CYCQPGFTGE RCEVSVCAGL CLNGGHCRAS KDEKEAPSCE CPAKFGGARC EQNSTEICTL
FCRLLKHEPE MYVPFGCHSI CEELAQDNST NIAVPQYQHL EVCLTPKVWT SSVIIILVIG
IVSSLLLVAV IVHGIRRLYK PKRPRIRKTF VVRKQARTNS AGDTPLTNRP LATEQCEITI
ENCCNMNICE TPCFDPKLVE QTLSKSSCKE DKKILIHNME DDLY
