CUE_DROMO
ID CUE_DROMO Reviewed; 634 AA.
AC B4L8V5;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Protein cueball {ECO:0000250|UniProtKB:Q95RU0};
DE Flags: Precursor;
GN Name=cue {ECO:0000250|UniProtKB:Q95RU0}; ORFNames=GI16721;
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230;
RN [1] {ECO:0000312|EMBL:EDW17130.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22 {ECO:0000312|EMBL:EDW17130.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Has a role in spermatogenesis and oogenesis.
CC {ECO:0000250|UniProtKB:Q95RU0}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cueball family. {ECO:0000305}.
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DR EMBL; CH933816; EDW17130.1; -; Genomic_DNA.
DR RefSeq; XP_002011999.1; XM_002011963.2.
DR AlphaFoldDB; B4L8V5; -.
DR SMR; B4L8V5; -.
DR STRING; 7230.FBpp0165938; -.
DR EnsemblMetazoa; FBtr0167446; FBpp0165938; FBgn0139469.
DR GeneID; 6586384; -.
DR KEGG; dmo:Dmoj_GI16721; -.
DR eggNOG; KOG1215; Eukaryota.
DR HOGENOM; CLU_026602_0_0_1; -.
DR InParanoid; B4L8V5; -.
DR OMA; KLYWTNS; -.
DR OrthoDB; 520442at2759; -.
DR PhylomeDB; B4L8V5; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0045938; P:positive regulation of circadian sleep/wake cycle, sleep; IEA:EnsemblMetazoa.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR GO; GO:0070328; P:triglyceride homeostasis; IEA:EnsemblMetazoa.
DR Gene3D; 2.120.10.30; -; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR Pfam; PF00058; Ldl_recept_b; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00135; LY; 3.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS51120; LDLRB; 3.
PE 3: Inferred from homology;
KW Cell membrane; Differentiation; Disulfide bond; EGF-like domain;
KW Glycoprotein; Membrane; Oogenesis; Reference proteome; Repeat; Signal;
KW Spermatogenesis; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..634
FT /note="Protein cueball"
FT /evidence="ECO:0000255"
FT /id="PRO_0000386573"
FT TOPO_DOM 28..515
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 516..536
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 537..634
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 122..169
FT /note="LDL-receptor class B 1"
FT /evidence="ECO:0000255"
FT REPEAT 170..214
FT /note="LDL-receptor class B 2"
FT /evidence="ECO:0000255"
FT REPEAT 215..260
FT /note="LDL-receptor class B 3"
FT /evidence="ECO:0000255"
FT DOMAIN 350..384
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 419..456
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 285
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 339
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 449
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 458
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 493
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 359..372
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 374..383
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 423..433
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 427..444
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 446..455
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 634 AA; 71613 MW; BDAFCE057EE442BD CRC64;
MKLCSLQQLV LAVLFIVSNF YLPLAVASPI GWDFAVTLRD KLLFLDNKFK TVSSAAHEFE
GISALAFDEA EEVIYFNDQQ HQNGSIFSLR RDAAVASHIV EQAVQRIGNG SVSGLAFDPL
NRNLFWADMR QSRIYFASVD TLHTEPPKVL VDLSAEGGRP DGVAVDICRR QLYWTNSKIN
HASVERIGLN GTGRQVIIKE NIDMPRGIVI DQQSDRIYWL DDKVGIFFAI ESARLDGSDR
QLVLEDKHQS PIQLAITDET IYWTDKADKA VWSYPKPANK KLATNATEPV VEPIKLASWK
EDVYGIVART GFYQHLQKDA HCASVVKKVK QRLDNRLNNR TQSRTAVDDR IEELEREHCL
NGATYMTKGN FCICQVGFKG ARCEISECHN YCVHGTCEIS SMGYPKCYCQ TDFYGERCEY
YKCNNHCLNG GHCTVDRDSG EMSCDCRDNF TGTRCEHNET AHCGSYCQHL KEHPDAFVPA
PCMDICEELR LTNATIVREY QSSAFCSDMP SYRQGSLIIV LVVGVVSSLA LVAVIVHGFR
LIHKPKRPRI KKTFVVRKQA RLNSTSDTPL TNRPLATEQC EITIENCCNM NICETPCFDP
KLVEQQFSGR DKKSPCVKED KKILIHNMED DLLN
