ID   CUG6A_CONCL             Reviewed;          13 AA.
AC   P0CI41;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   23-FEB-2022, entry version 24.
DE   RecName: Full=Omega-conotoxin Cl16a;
DE   AltName: Full=Conotoxin CalTx;
DE   AltName: Full=Omega-conotoxin Cl15a;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=20363338; DOI=10.1016/j.ympev.2010.03.029;
RA   Biggs J.S., Watkins M., Puillandre N., Ownby J.P., Lopez-Vera E.,
RA   Christensen S., Moreno K.J., Bernaldez J., Licea-Navarro A., Corneli P.S.,
RA   Olivera B.M.;
RT   "Evolution of Conus peptide toxins: analysis of Conus californicus Reeve,
RT   1844.";
RL   Mol. Phylogenet. Evol. 56:1-12(2010).
RN   [2]
RP   FUNCTION, AND TOXIN TARGET.
RC   TISSUE=Venom;
RX   PubMed=20920515; DOI=10.1016/j.toxicon.2010.09.015;
RA   Bernaldez J., Lopez O., Licea A., Salceda E., Arellano R.O., Vega R.,
RA   Soto E.;
RT   "Electrophysiological characterization of a novel small peptide from the
RT   venom of Conus californicus that targets voltage-gated neuronal Ca(2+)
RT   channels.";
RL   Toxicon 57:60-67(2011).
CC   -!- FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and
CC       block voltage-gated calcium channels (Cav). Reversibly blocks calcium
CC       current in the dorsal-root ganglion neurons of the rat (high voltage-
CC       activated channels but not low voltage-activated channels). Does not
CC       modify the voltage dependency of activation and inactivation.
CC       {ECO:0000269|PubMed:20920515}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20363338}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:20363338}.
CC   -!- DOMAIN: The cysteine framework is XVI (C-C-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds. {ECO:0000305}.
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DR   ConoServer; 4231; Cal16.2.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Presynaptic neurotoxin; Secreted;
KW   Toxin; Voltage-gated calcium channel impairing toxin.
FT   PEPTIDE         1..13
FT                   /note="Omega-conotoxin Cl16a"
FT                   /evidence="ECO:0000269|PubMed:20363338"
FT                   /id="PRO_0000402421"
SQ   SEQUENCE   13 AA;  1330 MW;  9E55FEFAB533A40E CRC64;
     NCPAGCRSQG CCM