ID   CUGA_CONCL              Reviewed;          65 AA.
AC   D2Y3T1; D2Y3T2;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Conotoxin Cal16.1 {ECO:0000303|PubMed:21172372};
DE   AltName: Full=Conotoxin Cal16a {ECO:0000303|PubMed:21172372};
DE   Flags: Precursor;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PYROGLUTAMATE FORMATION AT GLN-49, AMIDATION AT
RP   GLU-63, IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=21172372; DOI=10.1016/j.toxicon.2010.12.008;
RA   Elliger C.A., Richmond T.A., Lebaric Z.N., Pierce N.T., Sweedler J.V.,
RA   Gilly W.F.;
RT   "Diversity of conotoxin types from Conus californicus reflects a diversity
RT   of prey types and a novel evolutionary history.";
RL   Toxicon 57:311-322(2011).
CC   -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC       channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21172372}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:21172372}.
CC   -!- DOMAIN: The cysteine framework is XVI (C-C-CC). {ECO:0000305}.
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DR   EMBL; GU299513; ADB65788.1; -; mRNA.
DR   EMBL; GU299514; ADB65789.1; -; mRNA.
DR   AlphaFoldDB; D2Y3T1; -.
DR   ConoServer; 3987; Cal16.1 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Pyrrolidone carboxylic acid; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..48
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000566295"
FT   PEPTIDE         49..63
FT                   /note="Conotoxin Cal16.1"
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000570801"
FT   MOD_RES         49
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:21172372"
FT   MOD_RES         63
FT                   /note="Glutamic acid 1-amide"
FT                   /evidence="ECO:0000269|PubMed:21172372"
FT   DISULFID        51..60
FT                   /evidence="ECO:0000250|UniProtKB:P86942"
FT   DISULFID        53..61
FT                   /evidence="ECO:0000250|UniProtKB:P86942"
FT   CONFLICT        16..17
FT                   /note="FA -> SV (in Ref. 1; ADB65789)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   65 AA;  7253 MW;  C532036678A5C626 CRC64;
     MRCLSIFVLL VLLVSFAVAE LDVEGEIVKQ LLTRGTLKDA DFWKRLEMQG CVCNANAKFC
     CGEGR