ID   CUGA_CONQU              Reviewed;          11 AA.
AC   P0DJC3; P86140;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   22-APR-2020, entry version 15.
DE   RecName: Full=Conotoxin qc16a;
OS   Conus quercinus (Oak cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lividoconus.
OX   NCBI_TaxID=101313;
RN   [1]
RP   PROTEIN SEQUENCE, SYNTHESIS, FUNCTION, DISULFIDE BOND, MASS SPECTROMETRY,
RP   STRUCTURE BY NMR, MUTAGENESIS OF ASP-1; HIS-7 AND ASN-8, AND SUBCELLULAR
RP   LOCATION.
RC   TISSUE=Venom;
RX   PubMed=21524672; DOI=10.1016/j.peptides.2011.04.008;
RA   Ye M., Hong J., Zhou M., Huang L., Shao X., Yang Y., Sigworth F.J., Chi C.,
RA   Lin D., Wang C.;
RT   "A novel conotoxin, qc16a, with a unique cysteine framework and folding.";
RL   Peptides 32:1159-1165(2011).
CC   -!- FUNCTION: Causes reversible depression symptom in mice when injected
CC       intracranially. {ECO:0000269|PubMed:21524672}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21524672}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:21524672}.
CC   -!- DOMAIN: The cysteine framework is XVI (C-C-CC). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1174.5; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:21524672};
CC   -!- MISCELLANEOUS: Found in the dissected venom (DV).
CC   -!- MISCELLANEOUS: This toxin has no strong effect on the whole-cell
CC       currents of neurons and the currents of Drosophila Shaker channels,
CC       human BK channels (KCNM) and Nav1.7/SCN9A channels.
CC       {ECO:0000305|PubMed:21524672}.
CC   -!- WEB RESOURCE: Name=Biological Magnetic Resonance Data Bank;
CC       URL="http://www.bmrb.wisc.edu/data_library/summary/index.php?bmrbId=20128";
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..11
FT                   /note="Conotoxin qc16a"
FT                   /id="PRO_0000415308"
FT   SITE            1
FT                   /note="Essential for activity"
FT   SITE            7
FT                   /note="Essential for activity"
FT   SITE            8
FT                   /note="Essential for activity"
FT   DISULFID        2..11
FT                   /evidence="ECO:0000269|PubMed:21524672"
FT   DISULFID        5..10
FT                   /evidence="ECO:0000269|PubMed:21524672"
FT   MUTAGEN         1
FT                   /note="Missing: Has an abolished activity. Has an abolished
FT                   activity; when associated with A-7 or A-8."
FT                   /evidence="ECO:0000269|PubMed:21524672"
FT   MUTAGEN         7
FT                   /note="H->A: Has an abolished activity. Has an abolished
FT                   activity; when associated with Del-1."
FT                   /evidence="ECO:0000269|PubMed:21524672"
FT   MUTAGEN         8
FT                   /note="N->A: Has an excitatory activity before killing the
FT                   mice. Has an abolished activity; when associated with Del-
FT                   1."
FT                   /evidence="ECO:0000269|PubMed:21524672"
SQ   SEQUENCE   11 AA;  1178 MW;  2AB9799041E87EA7 CRC64;
     DCQPCGHNVC C