ID   CUMA_CONCL              Reviewed;          94 AA.
AC   D3JWK2;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Conotoxin Cal22a {ECO:0000303|PubMed:21172372};
DE   AltName: Full=Conotoxin Cl-S1 {ECO:0000303|PubMed:20363338};
DE   Flags: Precursor;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=20363338; DOI=10.1016/j.ympev.2010.03.029;
RA   Biggs J.S., Watkins M., Puillandre N., Ownby J.P., Lopez-Vera E.,
RA   Christensen S., Moreno K.J., Bernaldez J., Licea-Navarro A., Corneli P.S.,
RA   Olivera B.M.;
RT   "Evolution of Conus peptide toxins: analysis of Conus californicus Reeve,
RT   1844.";
RL   Mol. Phylogenet. Evol. 56:1-12(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=21172372; DOI=10.1016/j.toxicon.2010.12.008;
RA   Elliger C.A., Richmond T.A., Lebaric Z.N., Pierce N.T., Sweedler J.V.,
RA   Gilly W.F.;
RT   "Diversity of conotoxin types from Conus californicus reflects a diversity
RT   of prey types and a novel evolutionary history.";
RL   Toxicon 57:311-322(2011).
CC   -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC       channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21172372}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:21172372}.
CC   -!- DOMAIN: The cysteine framework is XXII (C-C-C-C-C-C-C-C).
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000305}.
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DR   EMBL; FJ959115; ADB93085.1; -; Genomic_DNA.
DR   EMBL; GU324074; ADB95946.1; -; mRNA.
DR   AlphaFoldDB; D3JWK2; -.
DR   ConoServer; 4001; Cal22a precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..44
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000570813"
FT   PEPTIDE         46..92
FT                   /note="Conotoxin Cal22a"
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000666520"
SQ   SEQUENCE   94 AA;  10319 MW;  23B9518F5E746A23 CRC64;
     MMSTKGITLF LCLLLLALAT SVNGGQGTRR SRMTRALHGG RPSARYDAPY CSQEEVRECH
     DDCSGNPVRD ACQCAYDPAG SPACDCYCVE PWRR