CUP4_CAEBR
ID CUP4_CAEBR Reviewed; 435 AA.
AC A8XF54;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Acetylcholine receptor-like protein cup-4;
DE AltName: Full=Coelomocyte uptake defective protein 4;
DE Flags: Precursor;
GN Name=cup-4 {ECO:0000250|UniProtKB:P34271}; ORFNames=CBG12273;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Thought to regulate endocytosis in coelomocytes through
CC modulation of phospholipase C activity. Possible acetylcholine receptor
CC (By similarity). {ECO:0000250|UniProtKB:P34271}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000250|UniProtKB:P34271}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P34271}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. {ECO:0000305}.
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DR EMBL; HE600962; CAP31276.2; -; Genomic_DNA.
DR AlphaFoldDB; A8XF54; -.
DR SMR; A8XF54; -.
DR EnsemblMetazoa; CBG12273.1; CBG12273.1; WBGene00033246.
DR WormBase; CBG12273; CBP25753; WBGene00033246; Cbr-cup-4.
DR eggNOG; KOG3645; Eukaryota.
DR HOGENOM; CLU_633456_0_0_1; -.
DR InParanoid; A8XF54; -.
DR OMA; VWQPKIK; -.
DR OrthoDB; 1028699at2759; -.
DR Proteomes; UP000008549; Chromosome III.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0098794; C:postsynapse; IEA:GOC.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:1901046; P:positive regulation of oviposition; IEA:EnsemblMetazoa.
DR GO; GO:0030100; P:regulation of endocytosis; ISS:UniProtKB.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0061771; P:response to caloric restriction; IEA:EnsemblMetazoa.
DR GO; GO:1901562; P:response to paraquat; IEA:EnsemblMetazoa.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR SUPFAM; SSF63712; SSF63712; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endocytosis; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..435
FT /note="Acetylcholine receptor-like protein cup-4"
FT /id="PRO_0000329000"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 237
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 249
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 403
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 435 AA; 50067 MW; 890059D87C97387C CRC64;
MRLLLIFTVI FVFYLAILKR DVNAQQQGID SEEGDAETFF NRTYSAHQSD LEKRIFRGYD
IKKRPVKNAS VPTVVDVHWH VIHVSINQKE QTMTLHGHIY MRWYDEYLVW DPKDFAGIHY
ARVKKWQVWQ PKIRVSNSAS GLASAFDFST SAHVIIQMVE KDRAKVEMYP TFSIKVGCMF
DFGDFPYDQN KCSVNLFATD TMAEVQLQNL YNIPPTLSFG WEEQKMKRII SDFKILNVSA
SQFYYGSGNV SKTAPVTGFE LGNTWSMLAV NVDFVRHSPY FWSTIVAPTL VCTMFIQVSF
FAPTVSLAFV INLMAIYLEF MFLQDITIKI PLYLSKRPSS ITLFHILLIS NIVSAVFHGV
LCALCSTKVP VPLPIRKIYA VKDYVPASWK EEGMVVDYAC DTNWTEWTRT ARPLAGLAMF
VYFVIMFILY LVVRI
