ID   CUP7_DROME              Reviewed;         122 AA.
AC   P27779; Q9VP54;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Pupal cuticle protein Edg-78E;
DE   Flags: Precursor;
GN   Name=Edg78E; Synonyms=EDG-78E; ORFNames=CG7673;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=Oregon-R;
RX   PubMed=1713868; DOI=10.1016/0012-1606(91)90257-4;
RA   Apple R.T., Fristrom J.W.;
RT   "20-Hydroxyecdysone is required for, and negatively regulates,
RT   transcription of Drosophila pupal cuticle protein genes.";
RL   Dev. Biol. 146:569-582(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC   -!- FUNCTION: Component of the cuticle of the pupa of fruit fly.
CC   -!- TISSUE SPECIFICITY: Imaginal (anterior) epidermis.
CC   -!- MISCELLANEOUS: The sequence shown is from genomic DNA.
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DR   EMBL; M71247; AAA28499.1; -; Genomic_DNA.
DR   EMBL; M71248; AAA28500.1; -; mRNA.
DR   EMBL; AE014296; AAF51702.1; -; Genomic_DNA.
DR   PIR; A49773; A49773.
DR   RefSeq; NP_001287140.1; NM_001300211.1.
DR   RefSeq; NP_524198.1; NM_079474.3.
DR   AlphaFoldDB; P27779; -.
DR   BioGRID; 65602; 1.
DR   DIP; DIP-19035N; -.
DR   IntAct; P27779; 1.
DR   STRING; 7227.FBpp0078062; -.
DR   PaxDb; P27779; -.
DR   DNASU; 40354; -.
DR   EnsemblMetazoa; FBtr0078408; FBpp0078062; FBgn0000551.
DR   EnsemblMetazoa; FBtr0344634; FBpp0310951; FBgn0000551.
DR   GeneID; 40354; -.
DR   KEGG; dme:Dmel_CG7673; -.
DR   CTD; 40354; -.
DR   FlyBase; FBgn0000551; Edg78E.
DR   VEuPathDB; VectorBase:FBgn0000551; -.
DR   eggNOG; ENOG502T7Y8; Eukaryota.
DR   HOGENOM; CLU_065450_3_1_1; -.
DR   InParanoid; P27779; -.
DR   OMA; YMICLAL; -.
DR   OrthoDB; 1459720at2759; -.
DR   PhylomeDB; P27779; -.
DR   BioGRID-ORCS; 40354; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 40354; -.
DR   PRO; PR:P27779; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0000551; Expressed in pupa and 7 other tissues.
DR   ExpressionAtlas; P27779; baseline and differential.
DR   Genevisible; P27779; DM.
DR   GO; GO:0062129; C:chitin-based extracellular matrix; ISM:FlyBase.
DR   GO; GO:0008010; F:structural constituent of chitin-based larval cuticle; ISM:FlyBase.
DR   GO; GO:0008011; F:structural constituent of pupal chitin-based cuticle; TAS:FlyBase.
DR   GO; GO:0040003; P:chitin-based cuticle development; ISM:FlyBase.
DR   InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR   InterPro; IPR000618; Insect_cuticle.
DR   Pfam; PF00379; Chitin_bind_4; 1.
DR   PRINTS; PR00947; CUTICLE.
DR   PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR   PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE   2: Evidence at transcript level;
KW   Cuticle; Reference proteome; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..122
FT                   /note="Pupal cuticle protein Edg-78E"
FT                   /id="PRO_0000006399"
FT   DOMAIN          36..96
FT                   /note="Chitin-binding type R&R"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
SQ   SEQUENCE   122 AA;  13347 MW;  CD68BC35B62F78E0 CRC64;
     MYKYLFCLAL IGCACADNIN KDAQIRSFQN DATDAEGNYQ YAYETSNGIQ IQEAGNANGA
     RGAVAYVSPE GEHISLTYTA DEEGYHPVGD HLPTPPPVPA YVLRALEYIR THPPAPAQKE
     QQ