CUP8_DROME
ID CUP8_DROME Reviewed; 188 AA.
AC P27780; Q9VI43;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Pupal cuticle protein Edg-84A;
DE Flags: Precursor;
GN Name=Edg84A; Synonyms=EDG-84A; ORFNames=CG2345;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Oregon-R;
RX PubMed=1713868; DOI=10.1016/0012-1606(91)90257-4;
RA Apple R.T., Fristrom J.W.;
RT "20-Hydroxyecdysone is required for, and negatively regulates,
RT transcription of Drosophila pupal cuticle protein genes.";
RL Dev. Biol. 146:569-582(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Berkeley;
RA Celniker S.E., Pfeiffer B., Knafels J., Martin C.H., Mayeda C.A.,
RA Palazzolo M.J.;
RT "Complete sequence of the Antennapedia complex of Drosophila.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Component of the cuticle of the pupa of fruit fly.
CC -!- TISSUE SPECIFICITY: Imaginal (anterior) epidermis.
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DR EMBL; M71249; AAA28501.1; -; Genomic_DNA.
DR EMBL; AE001572; AAD19810.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF54097.2; -; Genomic_DNA.
DR PIR; B49773; B49773.
DR RefSeq; NP_524247.1; NM_079523.3.
DR AlphaFoldDB; P27780; -.
DR STRING; 7227.FBpp0081186; -.
DR PaxDb; P27780; -.
DR DNASU; 40818; -.
DR EnsemblMetazoa; FBtr0081688; FBpp0081186; FBgn0000552.
DR GeneID; 40818; -.
DR KEGG; dme:Dmel_CG2345; -.
DR CTD; 40818; -.
DR FlyBase; FBgn0000552; Edg84A.
DR VEuPathDB; VectorBase:FBgn0000552; -.
DR eggNOG; ENOG502TDXQ; Eukaryota.
DR GeneTree; ENSGT00940000166457; -.
DR HOGENOM; CLU_075165_1_1_1; -.
DR InParanoid; P27780; -.
DR OMA; KTTVHHA; -.
DR OrthoDB; 1544103at2759; -.
DR PhylomeDB; P27780; -.
DR BioGRID-ORCS; 40818; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 40818; -.
DR PRO; PR:P27780; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0000552; Expressed in outer epithelium and 4 other tissues.
DR ExpressionAtlas; P27780; differential.
DR Genevisible; P27780; DM.
DR GO; GO:0062129; C:chitin-based extracellular matrix; ISM:FlyBase.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0008010; F:structural constituent of chitin-based larval cuticle; ISM:FlyBase.
DR GO; GO:0008011; F:structural constituent of pupal chitin-based cuticle; TAS:FlyBase.
DR GO; GO:0040003; P:chitin-based cuticle development; ISM:FlyBase.
DR InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR InterPro; IPR000618; Insect_cuticle.
DR Pfam; PF00379; Chitin_bind_4; 1.
DR PRINTS; PR00947; CUTICLE.
DR PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE 2: Evidence at transcript level;
KW Cuticle; Reference proteome; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..188
FT /note="Pupal cuticle protein Edg-84A"
FT /id="PRO_0000006400"
FT DOMAIN 34..100
FT /note="Chitin-binding type R&R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
FT REGION 19..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 188 AA; 20365 MW; 6C273FC9E09D012D CRC64;
MLVKTALFVT LIGLAQAGPL PAKSSGSEDT YDSHPQYSFN YDVQDPETGD VKSQSESRDG
DVVHGQYSVN DADGYRRTVD YTADDVRGFN AVVRREPLSS AAVVVKPQAT AVVPKVQLKP
LKKLPALKPL SQASAVVHRS FAPVVHHAPV THVVHHAAPA HSFVSHHVPV LKTTVHHAHH
PHAISYVF
