CUP9_DROME
ID CUP9_DROME Reviewed; 159 AA.
AC P27781; Q9VEI1;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2001, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Pupal cuticle protein Edg-91;
DE AltName: Full=Ecdysone-dependent protein 91;
DE Flags: Precursor;
GN Name=Edg91; Synonyms=EDG-91; ORFNames=CG7539;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=Oregon-R;
RX PubMed=1713868; DOI=10.1016/0012-1606(91)90257-4;
RA Apple R.T., Fristrom J.W.;
RT "20-Hydroxyecdysone is required for, and negatively regulates,
RT transcription of Drosophila pupal cuticle protein genes.";
RL Dev. Biol. 146:569-582(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Component of the pupal cuticle.
CC -!- TISSUE SPECIFICITY: Larval (posterior) and imaginal (anterior)
CC epidermis.
CC -!- DEVELOPMENTAL STAGE: Prepupal and early pupal stages.
CC -!- DOMAIN: This protein is glycine-rich and contains several repeats of
CC the motif (G/S)1-4(Y/F) like structural proteins from insect egg
CC shells, egg cases and vertebrate cytokeratins.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M71250; AAA28502.1; -; Genomic_DNA.
DR EMBL; M71251; AAA28503.1; -; mRNA.
DR EMBL; AE014297; AAF55440.1; -; Genomic_DNA.
DR PIR; C49773; C49773.
DR RefSeq; NP_524390.2; NM_079666.3.
DR AlphaFoldDB; P27781; -.
DR BioGRID; 67149; 1.
DR DIP; DIP-23842N; -.
DR IntAct; P27781; 1.
DR STRING; 7227.FBpp0082926; -.
DR PaxDb; P27781; -.
DR DNASU; 42117; -.
DR EnsemblMetazoa; FBtr0083502; FBpp0082926; FBgn0004554.
DR GeneID; 42117; -.
DR KEGG; dme:Dmel_CG7539; -.
DR CTD; 42117; -.
DR FlyBase; FBgn0004554; Edg91.
DR VEuPathDB; VectorBase:FBgn0004554; -.
DR BioGRID-ORCS; 42117; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 42117; -.
DR PRO; PR:P27781; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0004554; Expressed in larva and 7 other tissues.
DR ExpressionAtlas; P27781; baseline and differential.
DR Genevisible; P27781; DM.
DR GO; GO:0008011; F:structural constituent of pupal chitin-based cuticle; TAS:FlyBase.
PE 2: Evidence at transcript level;
KW Cuticle; Reference proteome; Signal.
FT SIGNAL 1..21
FT CHAIN 22..159
FT /note="Pupal cuticle protein Edg-91"
FT /id="PRO_0000006401"
FT CONFLICT 29
FT /note="S -> R (in Ref. 1; AAA28502/AAA28503)"
FT /evidence="ECO:0000305"
FT CONFLICT 109
FT /note="H -> Y (in Ref. 1; AAA28502/AAA28503)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 159 AA; 15260 MW; 266216A2A39AA06F CRC64;
MALVRVSCML ALLLIAGQGQ AAPVKTEGST LGLLGGGFGG SVGLSAGIGV GGGLYSGFGG
GGYPGGYASG YPGGYGGGYS GYNGYGGSGF GGGYYPGGGY SGFGHRPHHH GGYYPGGGSY
HNQGGSYGGH YSQSQYSNGY YGGGGYGGGG YGGNGFFGK
