CUPA_DICDI
ID CUPA_DICDI Reviewed; 423 AA.
AC Q55FW5; Q7Z1Z8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Calcium up-regulated protein A;
GN Name=cupA; ORFNames=DDB_G0267466;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, DEVELOPMENTAL
RP STAGE, AND INDUCTION.
RX PubMed=14871937; DOI=10.1128/ec.3.1.61-71.2004;
RA Coukell B., Li Y., Moniakis J., Cameron A.;
RT "The Ca2+/calcineurin-regulated cup gene family in Dictyostelium discoideum
RT and its possible involvement in development.";
RL Eukaryot. Cell 3:61-71(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May play an important role in stabilizing and/or regulating
CC the cell membrane during Ca(2+) stress or certain stages of
CC development. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14871937}. Membrane
CC {ECO:0000269|PubMed:14871937}; Peripheral membrane protein
CC {ECO:0000269|PubMed:14871937}. Note=Associates with the cell membrane
CC during Ca(2+) stress and cell aggregation.
CC -!- DEVELOPMENTAL STAGE: Expressed at high levels during aggregation and
CC late development and at low levels during the slug stage.
CC {ECO:0000269|PubMed:14871937}.
CC -!- INDUCTION: Induced by high levels of extracellular Ca(2+).
CC {ECO:0000269|PubMed:14871937}.
CC -!- SIMILARITY: Belongs to the cup family. {ECO:0000305}.
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DR EMBL; AY282574; AAP40296.1; -; Genomic_DNA.
DR EMBL; AAFI02000003; EAL73186.1; -; Genomic_DNA.
DR RefSeq; XP_647418.1; XM_642326.1.
DR AlphaFoldDB; Q55FW5; -.
DR STRING; 44689.DDB0191523; -.
DR CAZy; CBM13; Carbohydrate-Binding Module Family 13.
DR PaxDb; Q55FW5; -.
DR EnsemblProtists; EAL73186; EAL73186; DDB_G0267466.
DR GeneID; 8616225; -.
DR KEGG; ddi:DDB_G0267466; -.
DR dictyBase; DDB_G0267466; cupA.
DR HOGENOM; CLU_649610_0_0_1; -.
DR PhylomeDB; Q55FW5; -.
DR PRO; PR:Q55FW5; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0043157; P:response to cation stress; IDA:dictyBase.
DR CDD; cd00161; RICIN; 1.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SMART; SM00458; RICIN; 2.
DR SUPFAM; SSF50370; SSF50370; 2.
DR PROSITE; PS50231; RICIN_B_LECTIN; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Lectin; Membrane; Reference proteome; Repeat.
FT CHAIN 1..423
FT /note="Calcium up-regulated protein A"
FT /id="PRO_0000327949"
FT DOMAIN 27..147
FT /note="Ricin B-type lectin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT DOMAIN 118..251
FT /note="Ricin B-type lectin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 116
FT /note="Q -> K (in Ref. 1; AAP40296)"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="K -> Q (in Ref. 1; AAP40296)"
FT /evidence="ECO:0000305"
FT CONFLICT 217
FT /note="L -> F (in Ref. 1; AAP40296)"
FT /evidence="ECO:0000305"
FT CONFLICT 233
FT /note="Y -> H (in Ref. 1; AAP40296)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 423 AA; 47174 MW; CBA42D364E4C09C8 CRC64;
MINIEDISKS SNESEEKQLK STSTSSKPKY PFAAKSLFKG SNNIIPYYLS TSNTFQCVAS
ESIQTWLLSD DGHIFTSSGN FVLDVSSGGY FVELVQLNSN SKTQIWTIDT TNNKIQNQGN
GKYLDIDNLN ICVAPLNGNA TQKWTTFRRA PIPTGNWGYF QSKKLDSNNN YWGLSVLNNS
TSYNTSVVMN KVQAKSIGQI WQMTNDGHIL SRLDGNLVLD IGPSINGSKT NYYLNTNVYK
ANDLMQQWGI NENNQIFNQY YPNLCIGFVG ELGVDSTVNC VLAQPTSASD INFQWIANPT
YSLNQIVSEV PEPFPAYTSG DLLASYQYLS NDATNGYTDD IRSLYTSINV SLEHFYVNVS
NATCPSSIHS TEDFSNVQNQ IKNELTYAIN VRLVFDNYSD FYSKLFSQGS TNLTNLANLI
NVI
