CUPB_DICDI
ID CUPB_DICDI Reviewed; 769 AA.
AC Q7Z203; Q54GY5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Calcium up-regulated protein B;
GN Name=cupB; ORFNames=DDB_G0289815;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], POSSIBLE FUNCTION, SUBCELLULAR LOCATION,
RP DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=14871937; DOI=10.1128/ec.3.1.61-71.2004;
RA Coukell B., Li Y., Moniakis J., Cameron A.;
RT "The Ca2+/calcineurin-regulated cup gene family in Dictyostelium discoideum
RT and its possible involvement in development.";
RL Eukaryot. Cell 3:61-71(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May play an important role in stabilizing and/or regulating
CC the cell membrane during Ca(2+) stress or certain stages of
CC development.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14871937}. Membrane
CC {ECO:0000269|PubMed:14871937}; Peripheral membrane protein
CC {ECO:0000269|PubMed:14871937}. Note=Associates with the cell membrane
CC during Ca(2+) stress and cell aggregation.
CC -!- DEVELOPMENTAL STAGE: Expressed at high levels during aggregation and
CC late development and at low levels during the slug stage.
CC {ECO:0000269|PubMed:14871937}.
CC -!- INDUCTION: Induced by high levels of extracellular Ca(2+).
CC {ECO:0000269|PubMed:14871937}.
CC -!- SIMILARITY: Belongs to the cup family. {ECO:0000305}.
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DR EMBL; AY282568; AAP40290.1; -; Genomic_DNA.
DR EMBL; AAFI02000149; EAL62508.1; -; Genomic_DNA.
DR RefSeq; XP_636022.1; XM_630930.1.
DR AlphaFoldDB; Q7Z203; -.
DR STRING; 44689.DDB0191376; -.
DR CAZy; CBM13; Carbohydrate-Binding Module Family 13.
DR PaxDb; Q7Z203; -.
DR EnsemblProtists; EAL62508; EAL62508; DDB_G0289815.
DR GeneID; 8627348; -.
DR KEGG; ddi:DDB_G0289815; -.
DR dictyBase; DDB_G0289815; cupB.
DR HOGENOM; CLU_020711_0_0_1; -.
DR PhylomeDB; Q7Z203; -.
DR PRO; PR:Q7Z203; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0043157; P:response to cation stress; IDA:dictyBase.
DR GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR CDD; cd00161; RICIN; 1.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SUPFAM; SSF50370; SSF50370; 2.
DR PROSITE; PS50231; RICIN_B_LECTIN; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Lectin; Membrane; Reference proteome; Repeat.
FT CHAIN 1..769
FT /note="Calcium up-regulated protein B"
FT /id="PRO_0000327950"
FT DOMAIN 25..145
FT /note="Ricin B-type lectin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT DOMAIN 158..296
FT /note="Ricin B-type lectin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 769 AA; 85657 MW; 666D6AB8CBE87E92 CRC64;
MINIEDISKS SNQSEEKQLK STSSKPKYSF AAKSLFKGSN NITPYYLSTS NTFQCVASES
IQTWLLSDDG HIFTSSGNFV LDVSSGGYFV ELVQLNSNSK TQIWTIDTTN NKIQNQGNGK
YLDIDNLNIC VAPLNGNATQ QWTTFRRAPI PTGNWGYFQS KQMDSNNNYW GLSVLNNSKS
YNTSVVMNKV QAKSKGQIWQ MTNDGHILSR LDGSLVLDIG PSINGSTTNY YLDTNVYKAN
DLKQQWGINE NNQIFNQYYP NLCIGFVGEL GVDSTVNCVL AQPSSASDIN FQWITNPTYS
LNEIVSEVPE PFPAYTSGDL LASYQYLSNI ATSNFTDDIR SLYTGINVSL QSFLSIVTNA
TCPSSIHSTE DFSNVQNQIK TELIYAIDVR LVFENYSGFY SKLFSQGSSN LTNLANLINV
DMSSNQMVNA NYTDAITSVF YSLISEIPVG GSIIANIGQS AVEWGELISQ SNYQGASTYQ
VELSQLYSHL NTNYENEMAN AQSMKDTILQ DWGMMSKTYA LCFLPTNDPS SLNINGLNFE
KISDVASVAY EIAMIQMLLP TTYQIYFTPA GYWVPYSDGD FAYSDNSGTY IMATIEYSNS
YPPKELTDKL WNNGVSKQEF FWSAYGWNLA TSLTYYNMAN KFGNIYKLAF PTIKNFTGVP
MQFVMTNDGD NLCNFPVKTH FAKFFSIYYS CGDLGHHYFD IAVNDINDNK VANFTVDINL
EAIEGSYVSI KTGSLVVQPG YAVGNPICNQ GSYSLMFSAS ILIPIYKSE
