ID   CUPC_DICDI              Reviewed;         769 AA.
AC   Q7Z202; Q54HP9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Calcium up-regulated protein C;
GN   Name=cupC; ORFNames=DDB_G0289283;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND INDUCTION.
RX   PubMed=14871937; DOI=10.1128/ec.3.1.61-71.2004;
RA   Coukell B., Li Y., Moniakis J., Cameron A.;
RT   "The Ca2+/calcineurin-regulated cup gene family in Dictyostelium discoideum
RT   and its possible involvement in development.";
RL   Eukaryot. Cell 3:61-71(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May play an important role in stabilizing and/or regulating
CC       the cell membrane during Ca(2+) stress or certain stages of
CC       development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at high levels during aggregation and
CC       late development and at low levels during the slug stage.
CC       {ECO:0000269|PubMed:14871937}.
CC   -!- INDUCTION: Induced by high levels of extracellular Ca(2+).
CC       {ECO:0000269|PubMed:14871937}.
CC   -!- SIMILARITY: Belongs to the cup family. {ECO:0000305}.
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DR   EMBL; AY282569; AAP40291.1; -; Genomic_DNA.
DR   EMBL; AAFI02000136; EAL62788.1; -; Genomic_DNA.
DR   RefSeq; XP_636312.1; XM_631220.1.
DR   AlphaFoldDB; Q7Z202; -.
DR   SMR; Q7Z202; -.
DR   STRING; 44689.DDB0191377; -.
DR   CAZy; CBM13; Carbohydrate-Binding Module Family 13.
DR   PaxDb; Q7Z202; -.
DR   EnsemblProtists; EAL62788; EAL62788; DDB_G0289283.
DR   GeneID; 8627073; -.
DR   KEGG; ddi:DDB_G0289283; -.
DR   dictyBase; DDB_G0289283; cupC.
DR   HOGENOM; CLU_020711_0_0_1; -.
DR   PhylomeDB; Q7Z202; -.
DR   PRO; PR:Q7Z202; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0043157; P:response to cation stress; IDA:dictyBase.
DR   CDD; cd00161; RICIN; 1.
DR   InterPro; IPR035992; Ricin_B-like_lectins.
DR   InterPro; IPR000772; Ricin_B_lectin.
DR   Pfam; PF00652; Ricin_B_lectin; 1.
DR   SUPFAM; SSF50370; SSF50370; 2.
DR   PROSITE; PS50231; RICIN_B_LECTIN; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lectin; Membrane; Reference proteome; Repeat.
FT   CHAIN           1..769
FT                   /note="Calcium up-regulated protein C"
FT                   /id="PRO_0000327951"
FT   DOMAIN          25..145
FT                   /note="Ricin B-type lectin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT   DOMAIN          158..296
FT                   /note="Ricin B-type lectin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   769 AA;  85061 MW;  357E3DDFE2154AF6 CRC64;
     MINIEDISKS SNQSEEKQLK STSSKTKYPF AAKSLFKGSN NITPYYLSTS NTFQCVASES
     IQTWLLSDDG HIFTSSGNFV LDVSSGGYFV ELVQLNSNSK TQIWTIDTTN NKIQNQGNGK
     YLDIDNLNIC VAPLNGNATQ KWTTFRRAPI PTGNWGYFQS KKLDSNNNYW GLSVLNNSTS
     YNTSVVMNKV QAKSIGQIWQ MTNDGHILSR LDGNLVLDIG PSINGSKTNY YLNTNVYKAN
     DLMQQWGINE NNQIFNQYYP NLCIGFVGEL GVDSTVNCVL AQPTSAGNIN FQWIANPTYS
     LNQIVSEVPE PFPAYTSGDL LASYQYLSNI ATNGYTDDIR SLYTSINVSL EIFYVNVTNA
     TCPSSIHSTE DFSNVQNQIK NELTYAINVR LVFDNYSDFY SKLFSQGSTN LTNLANLINV
     DMSSDQVVNG DYTDAITSVF YAIISEIPIG GSIIANIGES AVEFGELDAE SNDSGPSTYQ
     VTLSKLYDHL NENYENEMAN AQSMKNTILQ DWGMMSKTFA LCFLPTNNPS SLNINGLDFQ
     KISTIASIAY QTAMIQMLLP TNYQIYFTPA GYYAPVSSDD YSYTDSTGTY IMAEIDNCNS
     HPPKALTDKL WNNGVSKQEV FTSSYGWNLA TSVTYYNMVG KYSGMFKLSF PTVKNFTSVP
     MQFVMTNGSD RVGTFNVKTH FAGLASTYYY SGALGHHYYD IAVIDINGNK VANFTVDNNL
     EALEGSYVSI KTNSLVVQPG YVVGNPTCNQ GSFSQGFAAS ILIPIYKSN