ID   CUPD_DICDI              Reviewed;         634 AA.
AC   Q54BF5; Q7Z201;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Calcium up-regulated protein D;
GN   Name=cupD; ORFNames=DDB_G0293536;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND INDUCTION.
RX   PubMed=14871937; DOI=10.1128/ec.3.1.61-71.2004;
RA   Coukell B., Li Y., Moniakis J., Cameron A.;
RT   "The Ca2+/calcineurin-regulated cup gene family in Dictyostelium discoideum
RT   and its possible involvement in development.";
RL   Eukaryot. Cell 3:61-71(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May play an important role in stabilizing and/or regulating
CC       the cell membrane during Ca(2+) stress or certain stages of
CC       development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at high levels during aggregation and
CC       late development and at low levels during the slug stage.
CC       {ECO:0000269|PubMed:14871937}.
CC   -!- INDUCTION: Induced by high levels of extracellular Ca(2+).
CC       {ECO:0000269|PubMed:14871937}.
CC   -!- SIMILARITY: Belongs to the cup family. {ECO:0000305}.
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DR   EMBL; AY282570; AAP40292.1; -; Genomic_DNA.
DR   EMBL; AAFI02000218; EAL60580.2; -; Genomic_DNA.
DR   RefSeq; XP_629074.3; XM_629072.2.
DR   AlphaFoldDB; Q54BF5; -.
DR   STRING; 44689.DDB0266357; -.
DR   CAZy; CBM13; Carbohydrate-Binding Module Family 13.
DR   PaxDb; Q54BF5; -.
DR   GeneID; 8629366; -.
DR   KEGG; ddi:DDB_G0293536; -.
DR   dictyBase; DDB_G0293536; cupD.
DR   PhylomeDB; Q54BF5; -.
DR   PRO; PR:Q54BF5; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0043157; P:response to cation stress; IDA:dictyBase.
DR   CDD; cd00161; RICIN; 1.
DR   InterPro; IPR035992; Ricin_B-like_lectins.
DR   InterPro; IPR000772; Ricin_B_lectin.
DR   Pfam; PF00652; Ricin_B_lectin; 1.
DR   SUPFAM; SSF50370; SSF50370; 2.
DR   PROSITE; PS50231; RICIN_B_LECTIN; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lectin; Membrane; Reference proteome; Repeat.
FT   CHAIN           1..634
FT                   /note="Calcium up-regulated protein D"
FT                   /id="PRO_0000327952"
FT   DOMAIN          27..146
FT                   /note="Ricin B-type lectin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT   DOMAIN          117..250
FT                   /note="Ricin B-type lectin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   634 AA;  70686 MW;  94C3593583BCA389 CRC64;
     MINIEDISKS SNQSEEKQLK STSTSSKPKY SFVAKSLFKG SNNITPYYLS TSNTFQCVAS
     ESIQTWLLSD DGHIFTSSGN FVLDVSSGGY FVELVQLNSN SKTQIWTIDT TNNKIQPGNG
     KYLDIDSLNI CVAPLNGNAT QKWTTFRRAP IPTGNWGYFQ SKQLDSNNNY WGLSVLNNST
     SYNTSVVMNK VQAKSIGQIW QMTNDGHILS RLDGNLVLDI GPSIDGSKTN YHLNTNVYKA
     NDLMQQWGIN ENNQIFNQYY PNLCIGFVGE LGVDSTVNCV LAQPSSASDI NFQWIANPTY
     SLNQIVSEVP EPFPAYTSGD LLASYQYLSD DATNGYTDDI RSLYTSINVN LEIFYVNVTN
     ATCPSSIHST EDFSYVQNQI KNELTYAINV RLVFDNYSGF YSKLFSQGST NLTNLANLIN
     VDMSSDQVVN GDYTDAITSV FYAIISEIPI GGSIIANISE SAVQFGELYA ESNDSGPSTY
     QVTLSKLYDH LNENYENEMA NAQRIKNTIL QDWGMMSKTF ALCFLPTNNP SSLNINGLDF
     QKISTIASLA YQTAIIQMLL PTNYQIYFTP AGYYAPVSSD DYSYTDSTGT YIMAEIDNCN
     SHPPKALTGF KTRSFHIFLW LEFSYLCDLL QYGR