CUPF_DICDI
ID CUPF_DICDI Reviewed; 769 AA.
AC Q7Z1I0; Q54GY4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Calcium up-regulated protein F;
GN Name=cupF; ORFNames=DDB_G0289813;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=14871937; DOI=10.1128/ec.3.1.61-71.2004;
RA Coukell B., Li Y., Moniakis J., Cameron A.;
RT "The Ca2+/calcineurin-regulated cup gene family in Dictyostelium discoideum
RT and its possible involvement in development.";
RL Eukaryot. Cell 3:61-71(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May play an important role in stabilizing and/or regulating
CC the cell membrane during Ca(2+) stress or certain stages of
CC development. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed at high levels during aggregation and
CC late development and at low levels during the slug stage.
CC {ECO:0000269|PubMed:14871937}.
CC -!- INDUCTION: Induced by high levels of extracellular Ca(2+).
CC {ECO:0000269|PubMed:14871937}.
CC -!- SIMILARITY: Belongs to the cup family. {ECO:0000305}.
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DR EMBL; AY282572; AAP40294.1; -; Genomic_DNA.
DR EMBL; AAFI02000149; EAL62507.1; -; Genomic_DNA.
DR RefSeq; XP_636023.1; XM_630931.1.
DR AlphaFoldDB; Q7Z1I0; -.
DR STRING; 44689.DDB0191378; -.
DR CAZy; CBM13; Carbohydrate-Binding Module Family 13.
DR PaxDb; Q7Z1I0; -.
DR PRIDE; Q7Z1I0; -.
DR EnsemblProtists; EAL62507; EAL62507; DDB_G0289813.
DR GeneID; 8627349; -.
DR KEGG; ddi:DDB_G0289813; -.
DR dictyBase; DDB_G0289813; cupF.
DR HOGENOM; CLU_020711_0_0_1; -.
DR OMA; YVWISEQ; -.
DR PhylomeDB; Q7Z1I0; -.
DR PRO; PR:Q7Z1I0; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0043157; P:response to cation stress; IDA:dictyBase.
DR CDD; cd00161; RICIN; 1.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF50370; SSF50370; 2.
DR PROSITE; PS50231; RICIN_B_LECTIN; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Lectin; Membrane; Reference proteome; Repeat.
FT CHAIN 1..769
FT /note="Calcium up-regulated protein F"
FT /id="PRO_0000327954"
FT DOMAIN 25..145
FT /note="Ricin B-type lectin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT DOMAIN 116..249
FT /note="Ricin B-type lectin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 715
FT /note="T -> S (in Ref. 1; AAP40294)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 769 AA; 85101 MW; 142BAA5A94341C4B CRC64;
MINIKDISKS SNQSEEKSLK GTSSKTKYPF AAKSLFKGSN NITPYYLSTS NTFQCVASES
IQTWLLSDDG HIFTSSGNFV LDVSSGGYFV ELVQLNSNSK TQIWTIDTTN NKIQNQGNGK
YLDIDNLKIC VAPLNGNATQ KWTTFRRAPI PTGNWGYFQS KQLDSNNNYW GLSVLNNSKS
YNTSVVMNKV QAKSIGQIWQ MTNDGHILSR LDGNLVLDIG PSINGSKTNY YLDTNVYKAN
DLKQQWGINE NNQIFNQYYP NLCIGFVGEL GVDSTVNCVL AQPSSASDIN FQWITNPTYS
LNEIVSEVPE PFPAYTSGDL LASYQYISNI ATNGHTDDIR SLYTSINVSL EIFYVNVTNA
TCPSSIHSTE DFSNVQNQIK NELTYAITVR LVFENYSGFY SKLFSQGSTN LTNLANLINV
DMSSDQVVNG DYTDAITSVF YAIISEIPIG GSIIANIGES AVEFGELYAE SNDSGPSTYQ
VTLSKLYDHL NENYENEMTN AQSMKNTILQ DWGMMSKTFA LCFLPTKNPS SLNINGLDFQ
KISTIASLAY QTAMIQMLLP TNYQIYFTPA GYYAPVSSDD YSYTDSTGTY IMAEIDNCNS
YPPKALTDKL WNNGVSKQEV FTSSYGWNLA TSVTYYNMVD KYSGMFKLSF PTVKNFTSVP
MQFVMTNGSD RVGTFNVKTH FAGLASTYYY SGALGHHYYD IAVTDIDGNK VANFTVDNNL
EALEGSYVSI KTGSLVVQPG YVVGNPTCNQ GSFSQGFAAS ILIPIYKSN
