ID   CUPG_DICDI              Reviewed;         768 AA.
AC   Q7Z1Z9; Q54GS6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Calcium up-regulated protein G;
GN   Name=cupG; ORFNames=DDB_G0289883;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND INDUCTION.
RX   PubMed=14871937; DOI=10.1128/ec.3.1.61-71.2004;
RA   Coukell B., Li Y., Moniakis J., Cameron A.;
RT   "The Ca2+/calcineurin-regulated cup gene family in Dictyostelium discoideum
RT   and its possible involvement in development.";
RL   Eukaryot. Cell 3:61-71(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May play an important role in stabilizing and/or regulating
CC       the cell membrane during Ca(2+) stress or certain stages of
CC       development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at high levels during aggregation and
CC       late development and at low levels during the slug stage.
CC       {ECO:0000269|PubMed:14871937}.
CC   -!- INDUCTION: Induced by high levels of extracellular Ca(2+).
CC       {ECO:0000269|PubMed:14871937}.
CC   -!- SIMILARITY: Belongs to the cup family. {ECO:0000305}.
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DR   EMBL; AY282573; AAP40295.1; -; Genomic_DNA.
DR   EMBL; AAFI02000149; EAL62454.1; -; Genomic_DNA.
DR   RefSeq; XP_635993.1; XM_630901.1.
DR   AlphaFoldDB; Q7Z1Z9; -.
DR   STRING; 44689.DDB0191379; -.
DR   CAZy; CBM13; Carbohydrate-Binding Module Family 13.
DR   PaxDb; Q7Z1Z9; -.
DR   EnsemblProtists; EAL62454; EAL62454; DDB_G0289883.
DR   GeneID; 8627408; -.
DR   KEGG; ddi:DDB_G0289883; -.
DR   dictyBase; DDB_G0289883; cupG.
DR   HOGENOM; CLU_020711_0_0_1; -.
DR   PhylomeDB; Q7Z1Z9; -.
DR   PRO; PR:Q7Z1Z9; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0043157; P:response to cation stress; IDA:dictyBase.
DR   CDD; cd00161; RICIN; 1.
DR   InterPro; IPR035992; Ricin_B-like_lectins.
DR   InterPro; IPR000772; Ricin_B_lectin.
DR   Pfam; PF00652; Ricin_B_lectin; 1.
DR   SUPFAM; SSF50370; SSF50370; 2.
DR   PROSITE; PS50231; RICIN_B_LECTIN; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lectin; Membrane; Reference proteome; Repeat.
FT   CHAIN           1..768
FT                   /note="Calcium up-regulated protein G"
FT                   /id="PRO_0000327955"
FT   DOMAIN          1..107
FT                   /note="Ricin B-type lectin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT   DOMAIN          100..248
FT                   /note="Ricin B-type lectin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   768 AA;  85414 MW;  3A228BF3E4C7BF31 CRC64;
     MINIEDISKS SNQSEEKQLK STSSKPKYSF AAKSLFKGSN NITPYYLSTS NTFQCVASES
     IQTWLLSDDG HIFTSSGNFV LDVSSGGYFV ELVQLNSNSK TQIWTIDTTN NKIQNQGNGN
     YLDIDCFNIC VAPLNGNATQ QWTTFRRAPI PTGNWGYFQS KQLNSNNYWG LSVLNNSTSY
     NTSVVMNKVQ AKSKGQIWQM TSDGHILSRL DGNLVLDIGP SINGSTTNYY LNTNVYKAND
     LMQQWGINEN NQIFNQYYPN LCIGFVGQLG VDSTVNCVLA QPSSACDTYF QFIANPTYSL
     NQIVGEVPEP FPAYTSGDLL ASYQYLSNDA TSNFTDDIRS LYTGINVSLQ SFLSIVTNAT
     CPSSIHSTED FSNVQNQIKT ELIYAINVRL VFENYSGFYS KLFSQGSSNL TNLANLINVD
     MSSNQMVNAN YTDAITSIFY SLISEIPVGG PIIANIGQSA VEFGELMSQS NYQGASTYQV
     ELSQLYTHLN TNYENEMANA QSMKDTILQD WGMMSKTYAL CFLPTNDPSS LNMNGLDFDE
     ISDVASVAYE IAMIQMLLPT TYQIYFTPAG YWVPYSDGDF AYSDNSGTYI MATIEYSNSY
     PPKELTDKLW NNGVSKQEFF LSAYGWNLAT SLTYYNNTKQ HNNIFKLAFP TIKNFTGVPM
     QFVMTNEGDN LGNFTVKTHF AKFFSTYYSC GEAGHHYFDI AVTDINKNKV ANFTVDIKLK
     ALEGSYVSIK TGSLVVQPGY AVGNPICNQG SYSLMFSASI LIPIYKSE