ID   CUPI_DICDI              Reviewed;         691 AA.
AC   Q75JP7; Q559M4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Putative calcium up-regulated protein I;
GN   Name=cupI; ORFNames=DDB_G0272242;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the cup family. {ECO:0000305}.
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DR   EMBL; AAFI02000008; EAL71273.1; -; Genomic_DNA.
DR   RefSeq; XP_645310.1; XM_640218.1.
DR   AlphaFoldDB; Q75JP7; -.
DR   SMR; Q75JP7; -.
DR   STRING; 44689.DDB0266361; -.
DR   PaxDb; Q75JP7; -.
DR   PRIDE; Q75JP7; -.
DR   EnsemblProtists; EAL71273; EAL71273; DDB_G0272242.
DR   GeneID; 8618476; -.
DR   KEGG; ddi:DDB_G0272242; -.
DR   dictyBase; DDB_G0272242; cupI.
DR   eggNOG; ENOG502R8B0; Eukaryota.
DR   HOGENOM; CLU_418846_0_0_1; -.
DR   InParanoid; Q75JP7; -.
DR   OMA; LMPSKYQ; -.
DR   PhylomeDB; Q75JP7; -.
DR   PRO; PR:Q75JP7; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0043157; P:response to cation stress; IBA:GO_Central.
DR   CDD; cd00161; RICIN; 1.
DR   InterPro; IPR035992; Ricin_B-like_lectins.
DR   InterPro; IPR000772; Ricin_B_lectin.
DR   Pfam; PF00652; Ricin_B_lectin; 1.
DR   SMART; SM00458; RICIN; 1.
DR   SUPFAM; SSF50370; SSF50370; 1.
DR   PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE   3: Inferred from homology;
KW   Lectin; Reference proteome.
FT   CHAIN           1..691
FT                   /note="Putative calcium up-regulated protein I"
FT                   /id="PRO_0000328255"
FT   DOMAIN          47..174
FT                   /note="Ricin B-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
SQ   SEQUENCE   691 AA;  76781 MW;  A7FAB3BC40CA6E1D CRC64;
     MSNKLNKQIS TEISECYLKE KPQQSFKKSN EIKMSNELIN KISNEISNCY LKEKPQQAKK
     ETKKKSIRSL PTDLPPLKSI TPLKSWIFLQ CRQMDANGNP LCCGVSGRYT QPGTQCILWQ
     IDENDPSQLW QISKDGHLVS LLAGNYVMDY NNDGTNLAIA NGWNNYTSQI WTYNSSTGQI
     ENSNYPNTCL GIKGAFNEPI TPTNGTELVI DQPIDNNNLC FQWDLVPSYP LNTILTSPPQ
     AFPTFPGDQN TAFIEISQYL SNVDDIRSQY TNLSVSLPFF QSQMSAMSYP SYLSHEEFDF
     VRDQLSTEFN YAQEIINLIG NYESFHNELF ADNSARLNQL ATLCQLEIGS DINAMGSVIQ
     VFSGMMYSIL EALPGVGPIL GNVLQTAVNI GVAASDGHST IQPDPFQVAL SNLWDTLSTN
     YEALLSNVSN METMLLQDWG MMVTTHGLIE TLSGPNSLAW QSSMTGDLIS AAVPGYEISL
     LQILMPSKYQ IYRYDLANNG NVGLPDDIPS SCLWTDPNDS NITYFIADNE TTKVYPDDSL
     MSLIWGNGVS EQEFFLSANG WNFCMSLLND NIGSGAPTIS NNTSTALNFK IQFSPTQIYN
     YDVPTHSSNF TTEFDNTAIE NSYYQITIYD NTNSWVASIS VRVDIFVMRG ADVSVLSSSC
     ADGYYLGTPN CLQGSFAHSF TGSINIPIFE N