ID   CUPP_DROPS              Reviewed;         192 AA.
AC   P16369; Q29P32;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Pupal cuticle protein;
DE   Flags: Precursor;
GN   Name=Pcp; ORFNames=GA17453;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=EST10;
RX   PubMed=3123310; DOI=10.1093/genetics/117.4.711;
RA   Henikoff S., Eghtedarzadeh M.K.;
RT   "Conserved arrangement of nested genes at the Drosophila Gart locus.";
RL   Genetics 117:711-725(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Component of the cuticle of the pupa of fruit fly.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout both the fourth and the fifth
CC       larval instars.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL34462.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; X06285; CAA29610.1; -; Genomic_DNA.
DR   EMBL; CH379058; EAL34462.2; ALT_SEQ; Genomic_DNA.
DR   PIR; S01205; UCFFPP.
DR   RefSeq; XP_001357393.3; XM_001357357.3.
DR   RefSeq; XP_015035470.1; XM_015179984.1.
DR   AlphaFoldDB; P16369; -.
DR   STRING; 7237.FBpp0278964; -.
DR   EnsemblMetazoa; FBtr0366166; FBpp0329385; FBgn0012707.
DR   EnsemblMetazoa; FBtr0370656; FBpp0333006; FBgn0012707.
DR   KEGG; dpo:Dpse_GA17453; -.
DR   eggNOG; ENOG502T8G8; Eukaryota.
DR   InParanoid; P16369; -.
DR   Proteomes; UP000001819; Genome assembly.
DR   Bgee; FBgn0012707; Expressed in female reproductive system and 1 other tissue.
DR   GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR   InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR   InterPro; IPR000618; Insect_cuticle.
DR   Pfam; PF00379; Chitin_bind_4; 1.
DR   PRINTS; PR00947; CUTICLE.
DR   PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR   PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE   2: Evidence at transcript level;
KW   Cuticle; Reference proteome; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..192
FT                   /note="Pupal cuticle protein"
FT                   /id="PRO_0000006398"
FT   DOMAIN          45..106
FT                   /note="Chitin-binding type R&R"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
FT   REGION          149..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        20
FT                   /note="V -> F (in Ref. 1; CAA29610)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   192 AA;  21476 MW;  E68A4EB934FF8FA9 CRC64;
     MHLLMSLFGV LAVMQQQLAV RAAAYIPDSD RNTKTLQNDL QVERDGNYRY AYETSNGISA
     TQEGLGGVSV QGGSSYTSPE GSVISVSYVA DETGYHPVGD HIPKVPDYIL RALEYIRAHP
     YQVKDYYTGE LKTVAHDAAA FNVYTRNIQD QTTPRSRPSS TPKTIYLTHP PTLSDAPTRR
     PLRQRQNDSR RR