ID   CUR1_YEAST              Reviewed;         252 AA.
AC   Q06469; D6W4F4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Curing of [URE3] protein 1;
GN   Name=CUR1; OrderedLocusNames=YPR158W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169875;
RA   Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA   Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA   Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA   Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA   DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA   Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA   Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA   Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA   Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA   Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA   Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA   Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA   Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA   Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA   Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA   Vo D.H., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL   Nature 387:103-105(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=18833194; DOI=10.1038/emboj.2008.198;
RA   Kryndushkin D.S., Shewmaker F., Wickner R.B.;
RT   "Curing of the [URE3] prion by Btn2p, a Batten disease-related protein.";
RL   EMBO J. 27:2725-2735(2008).
CC   -!- FUNCTION: Involved in the curing of prion [URE3]. Nuclear localization
CC       of this protein may suggest a role in transcription regulation, so it
CC       might exert an effect on [URE3] through known prion-curing chaperones
CC       or BTN2. {ECO:0000269|PubMed:18833194}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18833194}.
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DR   EMBL; U28371; AAB68055.1; -; Genomic_DNA.
DR   EMBL; BK006949; DAA11570.1; -; Genomic_DNA.
DR   PIR; S61142; S61142.
DR   RefSeq; NP_015484.1; NM_001184255.1.
DR   AlphaFoldDB; Q06469; -.
DR   BioGRID; 36325; 35.
DR   IntAct; Q06469; 1.
DR   STRING; 4932.YPR158W; -.
DR   PaxDb; Q06469; -.
DR   PRIDE; Q06469; -.
DR   EnsemblFungi; YPR158W_mRNA; YPR158W; YPR158W.
DR   GeneID; 856281; -.
DR   KEGG; sce:YPR158W; -.
DR   SGD; S000006362; CUR1.
DR   VEuPathDB; FungiDB:YPR158W; -.
DR   HOGENOM; CLU_1103307_0_0_1; -.
DR   OMA; QNDSAAN; -.
DR   BioCyc; YEAST:G3O-34289-MON; -.
DR   PRO; PR:Q06469; -.
DR   Proteomes; UP000002311; Chromosome XVI.
DR   RNAct; Q06469; protein.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0051087; F:chaperone binding; IPI:SGD.
DR   GO; GO:0006886; P:intracellular protein transport; IMP:SGD.
DR   GO; GO:0006457; P:protein folding; IMP:SGD.
DR   GO; GO:0034504; P:protein localization to nucleus; IMP:SGD.
PE   4: Predicted;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..252
FT                   /note="Curing of [URE3] protein 1"
FT                   /id="PRO_0000257830"
SQ   SEQUENCE   252 AA;  29163 MW;  86FD6CD25D5C7F19 CRC64;
     MAAACICQPN LLEINVSDGP LDMIRKKRKI QQPQLRPPLR ENKCQPHFSV RKVNQSYIIS
     LHKEITCQLI AEIVKQKLSR IWEKVYIPSY ELISDKDGNQ IYVEQSVDEN RLTSEIMEKL
     DPNNIDIEAI EILFDDYHLE LSRLTNGIII SSANDHFYRE FSFNNIIDDN FKICGTSMSA
     DSFDKIYGVM WIEVPFNGNG LQNDSAVNRV STSHNQIEEL NDIEQEIRAF NISRSNQESI
     IKKEVSRRLN GR