ID   CURR_ASPTE              Reviewed;         728 AA.
AC   L7X8G0;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2013, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Dehydrocurvularin biosynthesis regulator {ECO:0000303|PubMed:23335766};
GN   Name=curR {ECO:0000303|PubMed:23335766};
OS   Aspergillus terreus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=33178;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=AH-02-30-F7;
RX   PubMed=23335766; DOI=10.1128/aem.03334-12;
RA   Xu Y., Espinosa-Artiles P., Schubert V., Xu Y.M., Zhang W., Lin M.,
RA   Gunatilaka A.A., Sussmuth R., Molnar I.;
RT   "Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a
RT   heat shock response-modulating anticancer fungal polyketide from
RT   Aspergillus terreus.";
RL   Appl. Environ. Microbiol. 79:2038-2047(2013).
CC   -!- FUNCTION: Transcription factor involved in regulation of the
CC       dehydrocurvularin biosynthesis gene cluster (PubMed:23335766).
CC       {ECO:0000305|PubMed:23335766}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; JX971534; AGC95322.1; -; Genomic_DNA.
DR   AlphaFoldDB; L7X8G0; -.
DR   PRIDE; L7X8G0; -.
DR   VEuPathDB; FungiDB:ATEG_04564; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..728
FT                   /note="Dehydrocurvularin biosynthesis regulator"
FT                   /id="PRO_0000438392"
FT   DNA_BIND        28..58
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          75..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          606..626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..129
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        612..626
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   728 AA;  81784 MW;  375735DA10EC4DB4 CRC64;
     MSLSHVAPSH DAYGQAKRRK VRKGTHSCWE CKRRKMKCRF DPRIASACNG CRRRGSPCIS
     QEFPEDLEEA VMNIGTTSSD GTPFDGRTRA TTPSERTDQI LTPVSTVREP SQYPRSPEQH
     LPTGNDTSQR KYERLSRFLH ELLPSRADRE SIFKASRHSS ILSHELLTTP YITLHQNGLQ
     TPESLLMTPQ PNSHPVLIAR YMLQFALFLQ HLPPDLYKEI QGLSEPPRAT MERLADAAIY
     HVTTNEALIN SIESLECIML ESLYQVNLGN LRRSWVAGRR AMSLAQFMGF HRPDNQTRYY
     KALDPKTNYD PQIMWLRIII LDRQLCLLLG LPEGCTDHTM ASSETRIANN CPMGRLEQLH
     CVAMSRILDR NASQPSGRDL TATRAIDLEL QKAAGSLPSK WWLAPKLDSA STDLQAMFWD
     TRRLVLQICH YNLLNQLHLP YMLRPSTAGN KYEYSRITCV NASREVLSRY NSLRSFNRIA
     YSCRTVDFLA LMAAMALLLA HMDSYRDGAE NLLANQYLSD RGMIEQVQEH MSEINRLNSD
     ELSAQSADLL KSLLAIDLEK GKGRVSVREA GSEGMLPQDG MGPEEESVVR VHIPYFGIIR
     IAREKQHATT ASKPPVDRSP SSNSDAQLRF STLTHPSNAL PLSPNTTSNP LSFAVADAAA
     PHEFTTPFAH QQQQPCQPTF SNPGLSLTPS PLMQGGYPDL AAGSEDWAFQ RVDMAFFESI
     MRNVGGDL