ID   CUSB_ECOL6              Reviewed;         407 AA.
AC   Q8CWA2;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Cation efflux system protein CusB;
DE   Flags: Precursor;
GN   Name=cusB; OrderedLocusNames=c0660;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Part of a cation efflux system that mediates resistance to
CC       copper and silver. {ECO:0000250}.
CC   -!- SUBUNIT: The cus efflux system is composed of CusA, CusB, CusC and
CC       CusF. {ECO:0000250}.
CC   -!- INDUCTION: Transcriptionally regulated by CusR in response to copper
CC       and silver ions. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN79135.1; -; Genomic_DNA.
DR   RefSeq; WP_000717136.1; NC_004431.1.
DR   AlphaFoldDB; Q8CWA2; -.
DR   SMR; Q8CWA2; -.
DR   STRING; 199310.c0660; -.
DR   EnsemblBacteria; AAN79135; AAN79135; c0660.
DR   KEGG; ecc:c0660; -.
DR   eggNOG; COG0845; Bacteria.
DR   HOGENOM; CLU_018816_13_1_6; -.
DR   OMA; NTHQAIL; -.
DR   BioCyc; ECOL199310:C0660-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR043602; CusB_dom_1.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR045800; HMBD.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF00529; CusB_dom_1; 1.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   Pfam; PF19335; HMBD; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Copper; Copper transport; Ion transport; Signal; Transport.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..407
FT                   /note="Cation efflux system protein CusB"
FT                   /id="PRO_0000018692"
SQ   SEQUENCE   407 AA;  44410 MW;  4C8B4FF30C5E00E3 CRC64;
     MKKIALIIGS MIAGGIISAA GFTWFAKEEP PAEKTSTAER KVLFWYDPMY PNTRFDKPGK
     SPFMDMDLVP KYADEESSAS GVRIDPTQTQ NLGVKTATVT RGPLTFSQSF PANVSYNEYQ
     YAIVQARAAG FIDKVYPLTV GDKVQKGAPL LDLTIPDWVE AQSEYLLLRE TGGTATQTEG
     ILERLRLAGM PEADIRRLIA TQKIQTRFTL KAPIDGVITA FDLRAGMNIA KDNVVAKIQG
     MDPVWVTAAI PESIAWLVKD ASQFTLTVPA RPDKTLTIRK WTLLPGVDAA TRTLQLRLEV
     DNADEALKPG MNAWLQLNTA SEPMLLIPSQ ALIDTGNEQR VITVDADGRF VPKRVAVFQA
     SQGVTALRSG LAEGEKVVSS GLFLIDSEAN ISGALERMRS ESATHAH