ID   CUSF_ECOL6              Reviewed;         110 AA.
AC   Q8CWA3;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Cation efflux system protein CusF;
DE   Flags: Precursor;
GN   Name=cusF; Synonyms=cusX; OrderedLocusNames=c0659;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Part of a cation efflux system that mediates resistance to
CC       copper and silver. Binds one copper per polypeptide (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The cus efflux system is composed of CusA, CusB, CusC and
CC       CusF. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- INDUCTION: Transcriptionally regulated by CusR in response to copper
CC       and silver ions. {ECO:0000305}.
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DR   EMBL; AE014075; AAN79134.1; -; Genomic_DNA.
DR   RefSeq; WP_000709873.1; NC_004431.1.
DR   AlphaFoldDB; Q8CWA3; -.
DR   SMR; Q8CWA3; -.
DR   STRING; 199310.c0659; -.
DR   EnsemblBacteria; AAN79134; AAN79134; c0659.
DR   GeneID; 58391218; -.
DR   KEGG; ecc:c0659; -.
DR   eggNOG; COG5569; Bacteria.
DR   HOGENOM; CLU_140852_2_1_6; -.
DR   OMA; MHEQPAA; -.
DR   BioCyc; ECOL199310:C0659-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.320; -; 1.
DR   InterPro; IPR021647; CusF_Ec.
DR   InterPro; IPR042230; CusF_sf.
DR   Pfam; PF11604; CusF_Ec; 1.
PE   3: Inferred from homology;
KW   Copper; Metal-binding; Periplasm; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..110
FT                   /note="Cation efflux system protein CusF"
FT                   /id="PRO_0000021045"
SQ   SEQUENCE   110 AA;  12237 MW;  5BD003BABE05DB46 CRC64;
     MKKALQVAMF SLFTVIGFNA QANEHHHETM SEAQPQVISA TGVVKGVDLE SKKITIHHDP
     IAAVNWPEMT MRFTITPQTK MSEIKTGDKV AFNFVQQGNL SLLQDIKVSQ