CUTA_ECOLU
ID CUTA_ECOLU Reviewed; 112 AA.
AC B7NG75;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Divalent-cation tolerance protein CutA {ECO:0000255|HAMAP-Rule:MF_01160};
GN Name=cutA {ECO:0000255|HAMAP-Rule:MF_01160}; OrderedLocusNames=ECUMN_4672;
OS Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585056;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UMN026 / ExPEC;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Involved in resistance toward heavy metals.
CC {ECO:0000255|HAMAP-Rule:MF_01160}.
CC -!- COFACTOR:
CC Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01160};
CC Note=Binds 1 copper ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01160};
CC -!- SUBUNIT: Homotrimer. {ECO:0000255|HAMAP-Rule:MF_01160}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01160}.
CC -!- SIMILARITY: Belongs to the CutA family. {ECO:0000255|HAMAP-
CC Rule:MF_01160}.
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DR EMBL; CU928163; CAR15787.1; -; Genomic_DNA.
DR RefSeq; WP_000883400.1; NC_011751.1.
DR RefSeq; YP_002415271.1; NC_011751.1.
DR AlphaFoldDB; B7NG75; -.
DR SMR; B7NG75; -.
DR STRING; 585056.ECUMN_4672; -.
DR EnsemblBacteria; CAR15787; CAR15787; ECUMN_4672.
DR GeneID; 66671951; -.
DR KEGG; eum:ECUMN_4672; -.
DR PATRIC; fig|585056.7.peg.4835; -.
DR HOGENOM; CLU_098807_3_0_6; -.
DR OMA; VYTTFPD; -.
DR Proteomes; UP000007097; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005507; F:copper ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0010038; P:response to metal ion; IEA:InterPro.
DR Gene3D; 3.30.70.120; -; 1.
DR HAMAP; MF_01160; CutA; 1.
DR InterPro; IPR023700; CutA_Enterobact.
DR InterPro; IPR004323; Ion_tolerance_CutA.
DR InterPro; IPR011322; N-reg_PII-like_a/b.
DR InterPro; IPR015867; N-reg_PII/ATP_PRibTrfase_C.
DR PANTHER; PTHR23419; PTHR23419; 1.
DR Pfam; PF03091; CutA1; 1.
DR SUPFAM; SSF54913; SSF54913; 1.
PE 3: Inferred from homology;
KW Copper; Cytoplasm; Metal-binding.
FT CHAIN 1..112
FT /note="Divalent-cation tolerance protein CutA"
FT /id="PRO_1000137844"
FT BINDING 16
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01160"
FT BINDING 83
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01160"
FT BINDING 84
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01160"
SQ SEQUENCE 112 AA; 12331 MW; 802145EF012DDB69 CRC64;
MLDEKSSNTA SVVVLCTAPD EATAQDLAAK VLAEKLAACA TLIPGATSLY YWEGKLEQEY
EVQMILKTTV SHQQALLECL KSHHPYQTPE LLVLPVTHGD TDYLSWLNAS LR
