CUTA_MOUSE
ID CUTA_MOUSE Reviewed; 177 AA.
AC Q9CQ89; Q3TXB6; Q8CI44; Q9D1L4;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 3.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Protein CutA;
DE AltName: Full=Brain acetylcholinesterase putative membrane anchor;
DE Flags: Precursor;
GN Name=Cuta;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 15-177 (ISOFORM 2).
RC STRAIN=Czech II, and FVB/N-3; TISSUE=Lung, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CQ89-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CQ89-3; Sequence=VSP_013227, VSP_013228;
CC -!- MISCELLANEOUS: [Isoform 2]: Due to intron retention. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CutA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB22389.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB22913.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAE35000.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK002828; BAB22389.2; ALT_INIT; mRNA.
DR EMBL; AK003647; BAB22913.2; ALT_INIT; mRNA.
DR EMBL; AK004197; BAB23217.3; -; mRNA.
DR EMBL; AK159336; BAE35000.1; ALT_INIT; mRNA.
DR EMBL; BC024422; AAH24422.2; -; mRNA.
DR EMBL; BC037500; AAH37500.1; ALT_SEQ; mRNA.
DR CCDS; CCDS28557.1; -. [Q9CQ89-1]
DR RefSeq; NP_080583.3; NM_026307.3. [Q9CQ89-1]
DR RefSeq; NP_081224.1; NM_026948.3.
DR AlphaFoldDB; Q9CQ89; -.
DR SMR; Q9CQ89; -.
DR BioGRID; 212358; 10.
DR STRING; 10090.ENSMUSP00000025027; -.
DR PhosphoSitePlus; Q9CQ89; -.
DR EPD; Q9CQ89; -.
DR jPOST; Q9CQ89; -.
DR MaxQB; Q9CQ89; -.
DR PaxDb; Q9CQ89; -.
DR PeptideAtlas; Q9CQ89; -.
DR PRIDE; Q9CQ89; -.
DR ProteomicsDB; 285232; -. [Q9CQ89-1]
DR ProteomicsDB; 285233; -. [Q9CQ89-3]
DR Antibodypedia; 29177; 181 antibodies from 26 providers.
DR DNASU; 67675; -.
DR Ensembl; ENSMUST00000025027; ENSMUSP00000025027; ENSMUSG00000024194. [Q9CQ89-1]
DR GeneID; 67675; -.
DR KEGG; mmu:67675; -.
DR UCSC; uc008bex.2; mouse. [Q9CQ89-1]
DR CTD; 51596; -.
DR MGI; MGI:1914925; Cuta.
DR VEuPathDB; HostDB:ENSMUSG00000024194; -.
DR eggNOG; KOG3338; Eukaryota.
DR GeneTree; ENSGT00390000017030; -.
DR InParanoid; Q9CQ89; -.
DR OMA; HPYEVVE; -.
DR OrthoDB; 1589955at2759; -.
DR PhylomeDB; Q9CQ89; -.
DR TreeFam; TF313269; -.
DR BioGRID-ORCS; 67675; 5 hits in 73 CRISPR screens.
DR ChiTaRS; Cuta; mouse.
DR PRO; PR:Q9CQ89; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9CQ89; protein.
DR Bgee; ENSMUSG00000024194; Expressed in ectoplacental cone and 254 other tissues.
DR ExpressionAtlas; Q9CQ89; baseline and differential.
DR Genevisible; Q9CQ89; MM.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0005507; F:copper ion binding; IBA:GO_Central.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0008104; P:protein localization; ISO:MGI.
DR GO; GO:0010038; P:response to metal ion; IEA:InterPro.
DR Gene3D; 3.30.70.120; -; 1.
DR InterPro; IPR004323; Ion_tolerance_CutA.
DR InterPro; IPR011322; N-reg_PII-like_a/b.
DR InterPro; IPR015867; N-reg_PII/ATP_PRibTrfase_C.
DR PANTHER; PTHR23419; PTHR23419; 1.
DR Pfam; PF03091; CutA1; 1.
DR SUPFAM; SSF54913; SSF54913; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..177
FT /note="Protein CutA"
FT /id="PRO_0000006380"
FT VAR_SEQ 120..136
FT /note="MIKTQSSLVPALTEFVR -> VRKFPPCLAPLTTLALS (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_013227"
FT VAR_SEQ 137..177
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_013228"
FT CONFLICT 143
FT /note="V -> L (in Ref. 1; BAE35000)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 177 AA; 18865 MW; DCCE4AAD48C140C9 CRC64;
MNWGRAPGVL LGGGATLLLS FLWMPALLPV ASRLLLLPRA LLSMASGSPP SQPPPASGSG
YVPGSVSAAF VTCPNEKVAK EIARAVVEKR LAACVNLIPQ ITSIYEWKGK IEEDSEVLMM
IKTQSSLVPA LTEFVRSVHP YEVAEVIALP VEQGNPPYLH WVHQVTESVS NSGTALP
