ID   CUTA_SALTY              Reviewed;         115 AA.
AC   Q7CPA2;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Divalent-cation tolerance protein CutA {ECO:0000255|HAMAP-Rule:MF_01160};
GN   Name=cutA {ECO:0000255|HAMAP-Rule:MF_01160}; OrderedLocusNames=STM4324;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Involved in resistance toward heavy metals.
CC       {ECO:0000255|HAMAP-Rule:MF_01160}.
CC   -!- COFACTOR:
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01160};
CC       Note=Binds 1 copper ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01160};
CC   -!- SUBUNIT: Homotrimer. {ECO:0000255|HAMAP-Rule:MF_01160}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01160}.
CC   -!- SIMILARITY: Belongs to the CutA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01160}.
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DR   EMBL; AE006468; AAL23147.1; -; Genomic_DNA.
DR   RefSeq; NP_463188.1; NC_003197.2.
DR   RefSeq; WP_000887832.1; NC_003197.2.
DR   PDB; 3OPK; X-ray; 1.90 A; A/B/C=1-115.
DR   PDBsum; 3OPK; -.
DR   AlphaFoldDB; Q7CPA2; -.
DR   SMR; Q7CPA2; -.
DR   STRING; 99287.STM4324; -.
DR   PaxDb; Q7CPA2; -.
DR   EnsemblBacteria; AAL23147; AAL23147; STM4324.
DR   GeneID; 1255850; -.
DR   GeneID; 66758552; -.
DR   KEGG; stm:STM4324; -.
DR   PATRIC; fig|99287.12.peg.4549; -.
DR   HOGENOM; CLU_098807_3_0_6; -.
DR   OMA; VYTTFPD; -.
DR   PhylomeDB; Q7CPA2; -.
DR   BioCyc; SENT99287:STM4324-MON; -.
DR   EvolutionaryTrace; Q7CPA2; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005507; F:copper ion binding; IBA:GO_Central.
DR   GO; GO:0010038; P:response to metal ion; IEA:InterPro.
DR   Gene3D; 3.30.70.120; -; 1.
DR   HAMAP; MF_01160; CutA; 1.
DR   InterPro; IPR023700; CutA_Enterobact.
DR   InterPro; IPR004323; Ion_tolerance_CutA.
DR   InterPro; IPR011322; N-reg_PII-like_a/b.
DR   InterPro; IPR015867; N-reg_PII/ATP_PRibTrfase_C.
DR   PANTHER; PTHR23419; PTHR23419; 1.
DR   Pfam; PF03091; CutA1; 1.
DR   SUPFAM; SSF54913; SSF54913; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Copper; Cytoplasm; Metal-binding; Reference proteome.
FT   CHAIN           1..115
FT                   /note="Divalent-cation tolerance protein CutA"
FT                   /id="PRO_0000157124"
FT   BINDING         19
FT                   /ligand="Cu cation"
FT                   /ligand_id="ChEBI:CHEBI:23378"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01160"
FT   BINDING         86
FT                   /ligand="Cu cation"
FT                   /ligand_id="ChEBI:CHEBI:23378"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01160"
FT   BINDING         87
FT                   /ligand="Cu cation"
FT                   /ligand_id="ChEBI:CHEBI:23378"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01160"
FT   HELIX           5..7
FT                   /evidence="ECO:0007829|PDB:3OPK"
FT   STRAND          14..23
FT                   /evidence="ECO:0007829|PDB:3OPK"
FT   HELIX           24..36
FT                   /evidence="ECO:0007829|PDB:3OPK"
FT   STRAND          41..55
FT                   /evidence="ECO:0007829|PDB:3OPK"
FT   STRAND          58..72
FT                   /evidence="ECO:0007829|PDB:3OPK"
FT   HELIX           73..75
FT                   /evidence="ECO:0007829|PDB:3OPK"
FT   HELIX           76..86
FT                   /evidence="ECO:0007829|PDB:3OPK"
FT   STRAND          87..91
FT                   /evidence="ECO:0007829|PDB:3OPK"
FT   STRAND          94..98
FT                   /evidence="ECO:0007829|PDB:3OPK"
FT   HELIX           104..112
FT                   /evidence="ECO:0007829|PDB:3OPK"
SQ   SEQUENCE   115 AA;  12681 MW;  468E359192E5E74B CRC64;
     MLDVKSQDIS IPEAVVVLCT APDEATAQDL AAKVLAEKLA ACATLLPGAT SLYYWEGKLE
     QEYEVQMILK TTVSHQQALI DCLKSHHPYQ TPELLVLPVT HGDTDYLSWL NASLR