ID   CUTA_THEKO              Reviewed;         104 AA.
AC   Q5JDG6;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Divalent-cation tolerance protein CutA;
GN   Name=cutA; OrderedLocusNames=TK2032;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- FUNCTION: Involved in resistance toward heavy metals. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000305};
CC       Note=Binds 1 copper ion in the interface between two trimers.
CC       {ECO:0000305};
CC   -!- SUBUNIT: Homotrimer. The binding of the copper ion probably leads to
CC       oligomerization (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CutA family. {ECO:0000305}.
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DR   EMBL; AP006878; BAD86221.1; -; Genomic_DNA.
DR   RefSeq; WP_011250982.1; NC_006624.1.
DR   AlphaFoldDB; Q5JDG6; -.
DR   SMR; Q5JDG6; -.
DR   STRING; 69014.TK2032; -.
DR   EnsemblBacteria; BAD86221; BAD86221; TK2032.
DR   GeneID; 3235066; -.
DR   KEGG; tko:TK2032; -.
DR   PATRIC; fig|69014.16.peg.1986; -.
DR   eggNOG; arCOG04231; Archaea.
DR   HOGENOM; CLU_098807_3_1_2; -.
DR   InParanoid; Q5JDG6; -.
DR   OMA; VYTTFPD; -.
DR   OrthoDB; 110178at2157; -.
DR   PhylomeDB; Q5JDG6; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005507; F:copper ion binding; IBA:GO_Central.
DR   GO; GO:0010038; P:response to metal ion; IEA:InterPro.
DR   Gene3D; 3.30.70.120; -; 1.
DR   InterPro; IPR004323; Ion_tolerance_CutA.
DR   InterPro; IPR011322; N-reg_PII-like_a/b.
DR   InterPro; IPR015867; N-reg_PII/ATP_PRibTrfase_C.
DR   PANTHER; PTHR23419; PTHR23419; 1.
DR   Pfam; PF03091; CutA1; 1.
DR   SUPFAM; SSF54913; SSF54913; 1.
PE   3: Inferred from homology;
KW   Copper; Cytoplasm; Metal-binding; Reference proteome.
FT   CHAIN           1..104
FT                   /note="Divalent-cation tolerance protein CutA"
FT                   /id="PRO_0000157130"
SQ   SEQUENCE   104 AA;  12520 MW;  1B49BCEF89241868 CRC64;
     MEAIIVYTTF PDWESARKVT RELLERKLIV CANLREHEAM YWWEGKIEEG KEVGAIYKTE
     VSKWKELRET IKELHPYDVP MIARIDLDKL NREYSEWMAR VLFG