CUTA_THET8
ID CUTA_THET8 Reviewed; 103 AA.
AC Q7SIA8; Q5SIL3;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Divalent-cation tolerance protein CutA;
GN Name=cutA; OrderedLocusNames=TTHA1356;
OS Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=300852;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27634 / DSM 579 / HB8;
RA Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT "Complete genome sequence of Thermus thermophilus HB8.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
RA Bagautdinov B., Miyano M., Tahirov T.H.;
RT "Crystal structure of divalent cation tolerance protein (Cut A1) from
RT Thermus thermophilus HB8.";
RL Submitted (FEB-2003) to the PDB data bank.
CC -!- FUNCTION: Involved in resistance toward heavy metals. {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CutA family. {ECO:0000305}.
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DR EMBL; AP008226; BAD71179.1; -; Genomic_DNA.
DR RefSeq; WP_008632829.1; NC_006461.1.
DR RefSeq; YP_144622.1; NC_006461.1.
DR PDB; 1NZA; X-ray; 1.70 A; A=1-103.
DR PDB; 1V6H; X-ray; 1.90 A; A/B/C=1-103.
DR PDB; 4ZK7; X-ray; 3.40 A; M/N/O/P/Q/R/S/T/U/V/W/X=1-103.
DR PDBsum; 1NZA; -.
DR PDBsum; 1V6H; -.
DR PDBsum; 4ZK7; -.
DR AlphaFoldDB; Q7SIA8; -.
DR SMR; Q7SIA8; -.
DR STRING; 300852.55772738; -.
DR EnsemblBacteria; BAD71179; BAD71179; BAD71179.
DR GeneID; 3168527; -.
DR KEGG; ttj:TTHA1356; -.
DR PATRIC; fig|300852.9.peg.1333; -.
DR eggNOG; COG1324; Bacteria.
DR HOGENOM; CLU_098807_3_1_0; -.
DR OMA; VYTTFPD; -.
DR PhylomeDB; Q7SIA8; -.
DR EvolutionaryTrace; Q7SIA8; -.
DR Proteomes; UP000000532; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0010038; P:response to metal ion; IEA:InterPro.
DR Gene3D; 3.30.70.120; -; 1.
DR InterPro; IPR004323; Ion_tolerance_CutA.
DR InterPro; IPR011322; N-reg_PII-like_a/b.
DR InterPro; IPR015867; N-reg_PII/ATP_PRibTrfase_C.
DR PANTHER; PTHR23419; PTHR23419; 1.
DR Pfam; PF03091; CutA1; 1.
DR SUPFAM; SSF54913; SSF54913; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome.
FT CHAIN 1..103
FT /note="Divalent-cation tolerance protein CutA"
FT /id="PRO_0000157132"
FT STRAND 2..11
FT /evidence="ECO:0007829|PDB:1NZA"
FT HELIX 12..24
FT /evidence="ECO:0007829|PDB:1NZA"
FT STRAND 29..45
FT /evidence="ECO:0007829|PDB:1NZA"
FT STRAND 47..60
FT /evidence="ECO:0007829|PDB:1NZA"
FT TURN 61..63
FT /evidence="ECO:0007829|PDB:1NZA"
FT HELIX 64..74
FT /evidence="ECO:0007829|PDB:1NZA"
FT STRAND 75..79
FT /evidence="ECO:0007829|PDB:1NZA"
FT STRAND 82..86
FT /evidence="ECO:0007829|PDB:1NZA"
FT HELIX 92..100
FT /evidence="ECO:0007829|PDB:1NZA"
SQ SEQUENCE 103 AA; 11622 MW; 85646FE5600FFF57 CRC64;
MEEVVLITVP SEEVARTIAK ALVEERLAAC VNIVPGLTSI YRWQGEVVED QELLLLVKTT
THAFPKLKER VKALHPYTVP EIVALPIAEG NREYLDWLRE NTG
