CUTA_YERPE
ID CUTA_YERPE Reviewed; 119 AA.
AC Q74XD3; Q0WJW4; Q7CKN0; Q8ZIY8;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Divalent-cation tolerance protein CutA {ECO:0000255|HAMAP-Rule:MF_01160};
GN Name=cutA {ECO:0000255|HAMAP-Rule:MF_01160};
GN OrderedLocusNames=YPO0346, y0604, YP_0500;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Involved in resistance toward heavy metals.
CC {ECO:0000255|HAMAP-Rule:MF_01160}.
CC -!- COFACTOR:
CC Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01160};
CC Note=Binds 1 copper ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01160};
CC -!- SUBUNIT: Homotrimer. {ECO:0000255|HAMAP-Rule:MF_01160}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01160}.
CC -!- SIMILARITY: Belongs to the CutA family. {ECO:0000255|HAMAP-
CC Rule:MF_01160}.
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DR EMBL; AL590842; CAL19028.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84192.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS60770.1; -; Genomic_DNA.
DR PIR; AB0043; AB0043.
DR RefSeq; WP_002209122.1; NZ_WUCL01000014.1.
DR RefSeq; YP_002345424.1; NC_003143.1.
DR PDB; 3GSD; X-ray; 2.05 A; A/B/C/D/E/F/G/H/I/J/K/L=1-119.
DR PDBsum; 3GSD; -.
DR AlphaFoldDB; Q74XD3; -.
DR SMR; Q74XD3; -.
DR IntAct; Q74XD3; 6.
DR STRING; 214092.YPO0346; -.
DR PaxDb; Q74XD3; -.
DR DNASU; 1145551; -.
DR EnsemblBacteria; AAM84192; AAM84192; y0604.
DR EnsemblBacteria; AAS60770; AAS60770; YP_0500.
DR GeneID; 66843186; -.
DR KEGG; ype:YPO0346; -.
DR KEGG; ypk:y0604; -.
DR KEGG; ypm:YP_0500; -.
DR PATRIC; fig|214092.21.peg.582; -.
DR eggNOG; COG1324; Bacteria.
DR HOGENOM; CLU_098807_3_0_6; -.
DR OMA; VYTTFPD; -.
DR EvolutionaryTrace; Q74XD3; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005507; F:copper ion binding; IBA:GO_Central.
DR GO; GO:0010038; P:response to metal ion; IEA:InterPro.
DR Gene3D; 3.30.70.120; -; 1.
DR HAMAP; MF_01160; CutA; 1.
DR InterPro; IPR023700; CutA_Enterobact.
DR InterPro; IPR004323; Ion_tolerance_CutA.
DR InterPro; IPR011322; N-reg_PII-like_a/b.
DR InterPro; IPR015867; N-reg_PII/ATP_PRibTrfase_C.
DR PANTHER; PTHR23419; PTHR23419; 1.
DR Pfam; PF03091; CutA1; 1.
DR SUPFAM; SSF54913; SSF54913; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Copper; Cytoplasm; Metal-binding; Reference proteome.
FT CHAIN 1..119
FT /note="Divalent-cation tolerance protein CutA"
FT /id="PRO_0000157126"
FT BINDING 23
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01160"
FT BINDING 90
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01160"
FT BINDING 91
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01160"
FT STRAND 17..27
FT /evidence="ECO:0007829|PDB:3GSD"
FT HELIX 28..40
FT /evidence="ECO:0007829|PDB:3GSD"
FT STRAND 45..59
FT /evidence="ECO:0007829|PDB:3GSD"
FT STRAND 62..76
FT /evidence="ECO:0007829|PDB:3GSD"
FT HELIX 77..79
FT /evidence="ECO:0007829|PDB:3GSD"
FT HELIX 80..89
FT /evidence="ECO:0007829|PDB:3GSD"
FT STRAND 92..95
FT /evidence="ECO:0007829|PDB:3GSD"
FT STRAND 99..102
FT /evidence="ECO:0007829|PDB:3GSD"
FT HELIX 108..117
FT /evidence="ECO:0007829|PDB:3GSD"
SQ SEQUENCE 119 AA; 13173 MW; 59CB1DD130D2A815 CRC64;
MSDSDAMTDP NAVSYSNAIV VLCTAPDEAS AQNLAAQVLG EKLAACVTLL PGATSLYYWE
GKLEQEYEVQ LLFKSNTDHQ QALLTYIKQH HPYQTPELLV LPVRDGDKDY LSWLNASLL