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CUTA_YERPE
ID   CUTA_YERPE              Reviewed;         119 AA.
AC   Q74XD3; Q0WJW4; Q7CKN0; Q8ZIY8;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Divalent-cation tolerance protein CutA {ECO:0000255|HAMAP-Rule:MF_01160};
GN   Name=cutA {ECO:0000255|HAMAP-Rule:MF_01160};
GN   OrderedLocusNames=YPO0346, y0604, YP_0500;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Involved in resistance toward heavy metals.
CC       {ECO:0000255|HAMAP-Rule:MF_01160}.
CC   -!- COFACTOR:
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01160};
CC       Note=Binds 1 copper ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01160};
CC   -!- SUBUNIT: Homotrimer. {ECO:0000255|HAMAP-Rule:MF_01160}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01160}.
CC   -!- SIMILARITY: Belongs to the CutA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01160}.
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DR   EMBL; AL590842; CAL19028.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM84192.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS60770.1; -; Genomic_DNA.
DR   PIR; AB0043; AB0043.
DR   RefSeq; WP_002209122.1; NZ_WUCL01000014.1.
DR   RefSeq; YP_002345424.1; NC_003143.1.
DR   PDB; 3GSD; X-ray; 2.05 A; A/B/C/D/E/F/G/H/I/J/K/L=1-119.
DR   PDBsum; 3GSD; -.
DR   AlphaFoldDB; Q74XD3; -.
DR   SMR; Q74XD3; -.
DR   IntAct; Q74XD3; 6.
DR   STRING; 214092.YPO0346; -.
DR   PaxDb; Q74XD3; -.
DR   DNASU; 1145551; -.
DR   EnsemblBacteria; AAM84192; AAM84192; y0604.
DR   EnsemblBacteria; AAS60770; AAS60770; YP_0500.
DR   GeneID; 66843186; -.
DR   KEGG; ype:YPO0346; -.
DR   KEGG; ypk:y0604; -.
DR   KEGG; ypm:YP_0500; -.
DR   PATRIC; fig|214092.21.peg.582; -.
DR   eggNOG; COG1324; Bacteria.
DR   HOGENOM; CLU_098807_3_0_6; -.
DR   OMA; VYTTFPD; -.
DR   EvolutionaryTrace; Q74XD3; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005507; F:copper ion binding; IBA:GO_Central.
DR   GO; GO:0010038; P:response to metal ion; IEA:InterPro.
DR   Gene3D; 3.30.70.120; -; 1.
DR   HAMAP; MF_01160; CutA; 1.
DR   InterPro; IPR023700; CutA_Enterobact.
DR   InterPro; IPR004323; Ion_tolerance_CutA.
DR   InterPro; IPR011322; N-reg_PII-like_a/b.
DR   InterPro; IPR015867; N-reg_PII/ATP_PRibTrfase_C.
DR   PANTHER; PTHR23419; PTHR23419; 1.
DR   Pfam; PF03091; CutA1; 1.
DR   SUPFAM; SSF54913; SSF54913; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Copper; Cytoplasm; Metal-binding; Reference proteome.
FT   CHAIN           1..119
FT                   /note="Divalent-cation tolerance protein CutA"
FT                   /id="PRO_0000157126"
FT   BINDING         23
FT                   /ligand="Cu cation"
FT                   /ligand_id="ChEBI:CHEBI:23378"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01160"
FT   BINDING         90
FT                   /ligand="Cu cation"
FT                   /ligand_id="ChEBI:CHEBI:23378"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01160"
FT   BINDING         91
FT                   /ligand="Cu cation"
FT                   /ligand_id="ChEBI:CHEBI:23378"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01160"
FT   STRAND          17..27
FT                   /evidence="ECO:0007829|PDB:3GSD"
FT   HELIX           28..40
FT                   /evidence="ECO:0007829|PDB:3GSD"
FT   STRAND          45..59
FT                   /evidence="ECO:0007829|PDB:3GSD"
FT   STRAND          62..76
FT                   /evidence="ECO:0007829|PDB:3GSD"
FT   HELIX           77..79
FT                   /evidence="ECO:0007829|PDB:3GSD"
FT   HELIX           80..89
FT                   /evidence="ECO:0007829|PDB:3GSD"
FT   STRAND          92..95
FT                   /evidence="ECO:0007829|PDB:3GSD"
FT   STRAND          99..102
FT                   /evidence="ECO:0007829|PDB:3GSD"
FT   HELIX           108..117
FT                   /evidence="ECO:0007829|PDB:3GSD"
SQ   SEQUENCE   119 AA;  13173 MW;  59CB1DD130D2A815 CRC64;
     MSDSDAMTDP NAVSYSNAIV VLCTAPDEAS AQNLAAQVLG EKLAACVTLL PGATSLYYWE
     GKLEQEYEVQ LLFKSNTDHQ QALLTYIKQH HPYQTPELLV LPVRDGDKDY LSWLNASLL
 
 
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