ID   CUTC_CAEEL              Reviewed;         250 AA.
AC   P34630;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Copper homeostasis protein cutC homolog;
GN   Name=cutc-1; ORFNames=ZK353.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=18723824; DOI=10.1093/toxsci/kfn180;
RA   Calafato S., Swain S., Hughes S., Kille P., Sturzenbaum S.R.;
RT   "Knock down of Caenorhabditis elegans cutc-1 exacerbates the sensitivity
RT   toward high levels of copper.";
RL   Toxicol. Sci. 106:384-391(2008).
CC   -!- FUNCTION: Involved in copper homeostasis. Affects body morphology and
CC       length, egg laying and brood size. {ECO:0000269|PubMed:18723824}.
CC   -!- DISRUPTION PHENOTYPE: Reduced copper tolerance, which results in
CC       reduced brood size and retarded body length, protruding vulva (pvl)
CC       phenotype. {ECO:0000269|PubMed:18723824}.
CC   -!- SIMILARITY: Belongs to the CutC family. {ECO:0000305}.
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DR   EMBL; FO081668; CCD73206.1; -; Genomic_DNA.
DR   PIR; S44656; S44656.
DR   RefSeq; NP_498855.1; NM_066454.5.
DR   AlphaFoldDB; P34630; -.
DR   SMR; P34630; -.
DR   BioGRID; 41390; 1.
DR   DIP; DIP-25191N; -.
DR   STRING; 6239.ZK353.7; -.
DR   EPD; P34630; -.
DR   PaxDb; P34630; -.
DR   PeptideAtlas; P34630; -.
DR   EnsemblMetazoa; ZK353.7.1; ZK353.7.1; WBGene00022702.
DR   GeneID; 176186; -.
DR   KEGG; cel:CELE_ZK353.7; -.
DR   CTD; 176186; -.
DR   WormBase; ZK353.7; CE00391; WBGene00022702; cutc-1.
DR   eggNOG; KOG4013; Eukaryota.
DR   GeneTree; ENSGT00390000008454; -.
DR   HOGENOM; CLU_050555_3_1_1; -.
DR   InParanoid; P34630; -.
DR   OMA; FHRAFDQ; -.
DR   OrthoDB; 1619869at2759; -.
DR   PhylomeDB; P34630; -.
DR   PRO; PR:P34630; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00022702; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0030054; C:cell junction; HDA:WormBase.
DR   GO; GO:0005737; C:cytoplasm; ISS:WormBase.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005634; C:nucleus; ISS:WormBase.
DR   GO; GO:0055120; C:striated muscle dense body; HDA:WormBase.
DR   GO; GO:0005507; F:copper ion binding; IBA:GO_Central.
DR   GO; GO:0055070; P:copper ion homeostasis; IMP:WormBase.
DR   GO; GO:0035264; P:multicellular organism growth; IMP:WormBase.
DR   GO; GO:0032504; P:multicellular organism reproduction; IMP:WormBase.
DR   GO; GO:0018991; P:oviposition; IMP:WormBase.
DR   GO; GO:0046688; P:response to copper ion; IMP:WormBase.
DR   GO; GO:0040025; P:vulval development; IMP:WormBase.
DR   Gene3D; 3.20.20.380; -; 1.
DR   HAMAP; MF_00795; CutC; 1.
DR   InterPro; IPR005627; Cu_homeostasis_CutC.
DR   InterPro; IPR036822; CutC_dom_sf.
DR   PANTHER; PTHR12598; PTHR12598; 1.
DR   Pfam; PF03932; CutC; 1.
DR   SUPFAM; SSF110395; SSF110395; 1.
PE   3: Inferred from homology;
KW   Copper; Reference proteome.
FT   CHAIN           1..250
FT                   /note="Copper homeostasis protein cutC homolog"
FT                   /id="PRO_0000215090"
SQ   SEQUENCE   250 AA;  27262 MW;  E21CD42F4FCE5F15 CRC64;
     MTETESQKQI KLEICIDNLE SAENAVAGGA DRLEVCSALQ LGGLTPSVGF VSILSYKYPD
     IPLYCMIRQR AGDFVYNEDE MAANMEDVEW LKKAGATGFV FGALTSAGSL DRTSCQSIIE
     TARPHPVTFH RAIDVAYDWK TCLEDAIDVG FKAVLTSGQE PSALDGVYII REMQELHKGK
     IDVLAGCGVN SSNVANLVEW TKCHWYHASA SVAKKNAPLN KVSMGKQDNQ PSRVTSLEEV
     RMLKATLAPV