ID   CUTC_DROME              Reviewed;         263 AA.
AC   Q9VF71;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Copper homeostasis protein cutC homolog;
GN   ORFNames=CG6136;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Head;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- FUNCTION: Involved in copper homeostasis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CutC family. {ECO:0000305}.
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DR   EMBL; AE014297; AAF55189.1; -; Genomic_DNA.
DR   EMBL; AY070500; AAL47971.1; -; mRNA.
DR   EMBL; AY119472; AAM50126.1; -; mRNA.
DR   RefSeq; NP_001189224.1; NM_001202295.2.
DR   RefSeq; NP_001262600.1; NM_001275671.1.
DR   RefSeq; NP_650460.1; NM_142203.4.
DR   AlphaFoldDB; Q9VF71; -.
DR   SMR; Q9VF71; -.
DR   STRING; 7227.FBpp0292328; -.
DR   PaxDb; Q9VF71; -.
DR   DNASU; 41877; -.
DR   EnsemblMetazoa; FBtr0303235; FBpp0292327; FBgn0038332.
DR   EnsemblMetazoa; FBtr0303236; FBpp0292328; FBgn0038332.
DR   EnsemblMetazoa; FBtr0332540; FBpp0304807; FBgn0038332.
DR   GeneID; 41877; -.
DR   KEGG; dme:Dmel_CG6136; -.
DR   UCSC; CG6136-RA; d. melanogaster.
DR   FlyBase; FBgn0038332; CG6136.
DR   VEuPathDB; VectorBase:FBgn0038332; -.
DR   eggNOG; KOG4013; Eukaryota.
DR   GeneTree; ENSGT00390000008454; -.
DR   HOGENOM; CLU_050555_3_2_1; -.
DR   InParanoid; Q9VF71; -.
DR   OMA; FHRAFDQ; -.
DR   OrthoDB; 1619869at2759; -.
DR   PhylomeDB; Q9VF71; -.
DR   BioGRID-ORCS; 41877; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 41877; -.
DR   PRO; PR:Q9VF71; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0038332; Expressed in testis and 16 other tissues.
DR   ExpressionAtlas; Q9VF71; baseline and differential.
DR   Genevisible; Q9VF71; DM.
DR   GO; GO:0005507; F:copper ion binding; IBA:GO_Central.
DR   Gene3D; 3.20.20.380; -; 1.
DR   HAMAP; MF_00795; CutC; 1.
DR   InterPro; IPR005627; Cu_homeostasis_CutC.
DR   InterPro; IPR036822; CutC_dom_sf.
DR   PANTHER; PTHR12598; PTHR12598; 1.
DR   Pfam; PF03932; CutC; 1.
DR   SUPFAM; SSF110395; SSF110395; 1.
PE   2: Evidence at transcript level;
KW   Copper; Reference proteome.
FT   CHAIN           1..263
FT                   /note="Copper homeostasis protein cutC homolog"
FT                   /id="PRO_0000215091"
SQ   SEQUENCE   263 AA;  28916 MW;  5F6BD24FFE4C736F CRC64;
     MIREMSNHDI KLEVCVDSIR SAFAAEEGGA SRIELCSALG EGGLTPSIGT LKTIKETLTM
     PIYCMLRPRR GTDFVYSDEE MCALLTDMDL LRENGADGFV FGSLNPDRSI NVDQCRHVLL
     ASGGLPVTFH RAFDLTDQKS MDENVDMLRE LGFRRLLSSG FRPTAADGVD CLAQLIAKHQ
     RDFIVMPGAG IKVSNLEEIL TVSRCLEFHA SALDTAGEDY VAPTTTRMEC DVTMGKQDVD
     PYYGTNSIVV RKMVTIAKAM SSR