CUTC_ENTFA
ID CUTC_ENTFA Reviewed; 209 AA.
AC Q830V2;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=PF03932 family protein CutC {ECO:0000255|HAMAP-Rule:MF_00795};
DE AltName: Full=Putative copper homeostasis protein CutC {ECO:0000305|PubMed:21362400};
GN Name=cutC {ECO:0000255|HAMAP-Rule:MF_00795, ECO:0000303|PubMed:21362400};
GN OrderedLocusNames=EF_2667 {ECO:0000312|EMBL:AAO82374.1};
OS Enterococcus faecalis (strain ATCC 700802 / V583).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=226185;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700802 / V583;
RX PubMed=12663927; DOI=10.1126/science.1080613;
RA Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT faecalis.";
RL Science 299:2071-2074(2003).
RN [2]
RP PUTATIVE FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 700802 / V583;
RX PubMed=21362400; DOI=10.1016/j.bbrc.2011.02.109;
RA Latorre M., Olivares F., Reyes-Jara A., Lopez G., Gonzalez M.;
RT "CutC is induced late during copper exposure and can modify intracellular
RT copper content in Enterococcus faecalis.";
RL Biochem. Biophys. Res. Commun. 406:633-637(2011).
CC -!- FUNCTION: Might participate in the control of copper homeostasis; data
CC from other bacteria suggests it is not involved.
CC {ECO:0000305|PubMed:21362400}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00795}.
CC -!- INDUCTION: Induced late during copper exposure.
CC {ECO:0000269|PubMed:21362400}.
CC -!- DISRUPTION PHENOTYPE: Mutant shows a significant increase in the
CC intracellular copper concentration after 90 and 135 min of exposure to
CC copper. {ECO:0000269|PubMed:21362400}.
CC -!- SIMILARITY: Belongs to the CutC family. {ECO:0000255|HAMAP-
CC Rule:MF_00795, ECO:0000305}.
CC -!- CAUTION: Once thought to be involved in copper homeostasis, experiments
CC in E.coli have shown this is not the case. {ECO:0000255|HAMAP-
CC Rule:MF_00795}.
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DR EMBL; AE016830; AAO82374.1; -; Genomic_DNA.
DR RefSeq; NP_816304.1; NC_004668.1.
DR RefSeq; WP_002356490.1; NZ_KE136528.1.
DR AlphaFoldDB; Q830V2; -.
DR SMR; Q830V2; -.
DR STRING; 226185.EF_2667; -.
DR EnsemblBacteria; AAO82374; AAO82374; EF_2667.
DR KEGG; efa:EF2667; -.
DR PATRIC; fig|226185.45.peg.894; -.
DR eggNOG; COG3142; Bacteria.
DR HOGENOM; CLU_050555_2_0_9; -.
DR OMA; FHRAFDQ; -.
DR Proteomes; UP000001415; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.20.20.380; -; 1.
DR HAMAP; MF_00795; CutC; 1.
DR InterPro; IPR005627; Cu_homeostasis_CutC.
DR InterPro; IPR036822; CutC_dom_sf.
DR PANTHER; PTHR12598; PTHR12598; 1.
DR Pfam; PF03932; CutC; 1.
DR SUPFAM; SSF110395; SSF110395; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..209
FT /note="PF03932 family protein CutC"
FT /id="PRO_0000442179"
SQ SEQUENCE 209 AA; 22906 MW; 6BF4F26300945D4D CRC64;
MIKEFCAENF TKIPQAIQKG ANRIELCDNL AVGGTTPSTG VIEEVLAYAG EHSVPVMTII
RPRGGNFVYN DIELKIMHTD LIEAKKLGTD GIVIGCLTED GWLDEEALDL FIETAEGLQI
TFHMAFDALS KENQFKAIDW LAERGVTRIL THGGPAGTPI EDNFDHLKEL IVYADQRILI
LPGGGISTEN VQTVMDTLKV TEVHGTKIV
