CUTC_MOUSE
ID CUTC_MOUSE Reviewed; 272 AA.
AC Q9D8X1;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Copper homeostasis protein cutC homolog;
GN Name=Cutc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in copper homeostasis. Can bind one Cu(1+)
CC per subunit (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CutC family. {ECO:0000305}.
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DR EMBL; AK007591; BAB25124.1; -; mRNA.
DR EMBL; BC026775; AAH26775.1; -; mRNA.
DR CCDS; CCDS50443.1; -.
DR RefSeq; NP_001107034.1; NM_001113562.1.
DR AlphaFoldDB; Q9D8X1; -.
DR SMR; Q9D8X1; -.
DR BioGRID; 211434; 7.
DR IntAct; Q9D8X1; 1.
DR STRING; 10090.ENSMUSP00000107678; -.
DR iPTMnet; Q9D8X1; -.
DR PhosphoSitePlus; Q9D8X1; -.
DR EPD; Q9D8X1; -.
DR MaxQB; Q9D8X1; -.
DR PaxDb; Q9D8X1; -.
DR PeptideAtlas; Q9D8X1; -.
DR PRIDE; Q9D8X1; -.
DR ProteomicsDB; 279302; -.
DR Antibodypedia; 31094; 192 antibodies from 23 providers.
DR DNASU; 66388; -.
DR Ensembl; ENSMUST00000112047; ENSMUSP00000107678; ENSMUSG00000025193.
DR GeneID; 66388; -.
DR KEGG; mmu:66388; -.
DR UCSC; uc008hov.2; mouse.
DR CTD; 51076; -.
DR MGI; MGI:1913638; Cutc.
DR VEuPathDB; HostDB:ENSMUSG00000025193; -.
DR eggNOG; KOG4013; Eukaryota.
DR GeneTree; ENSGT00390000008454; -.
DR InParanoid; Q9D8X1; -.
DR OMA; FHRAFDQ; -.
DR OrthoDB; 1619869at2759; -.
DR PhylomeDB; Q9D8X1; -.
DR TreeFam; TF105937; -.
DR BioGRID-ORCS; 66388; 4 hits in 70 CRISPR screens.
DR ChiTaRS; Cutc; mouse.
DR PRO; PR:Q9D8X1; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9D8X1; protein.
DR Bgee; ENSMUSG00000025193; Expressed in spermatid and 217 other tissues.
DR ExpressionAtlas; Q9D8X1; baseline and differential.
DR Genevisible; Q9D8X1; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR GO; GO:0051262; P:protein tetramerization; ISO:MGI.
DR Gene3D; 3.20.20.380; -; 1.
DR HAMAP; MF_00795; CutC; 1.
DR InterPro; IPR005627; Cu_homeostasis_CutC.
DR InterPro; IPR036822; CutC_dom_sf.
DR PANTHER; PTHR12598; PTHR12598; 1.
DR Pfam; PF03932; CutC; 1.
DR SUPFAM; SSF110395; SSF110395; 1.
PE 1: Evidence at protein level;
KW Copper; Cytoplasm; Metal-binding; Nucleus; Reference proteome.
FT CHAIN 1..272
FT /note="Copper homeostasis protein cutC homolog"
FT /id="PRO_0000215089"
SQ SEQUENCE 272 AA; 29004 MW; 7FE099BCDDA2512C CRC64;
MKKGASCERK QAWISSGKAG AGNGFLMEVC VDSVESAVNA ERGGAGRIEL CSGLLEGGTT
PSMGVLQVVK QSVQIPVFVM IRPRGGDFLY SDREVEVMKA DIRLAKLYGA DGLVFGALTE
DGHIDKELCL SLVALCRPLP VTFHRAFDMV HDPMAALETL LTLGFERVLT SGCDSSALEG
LPLIKQLIDQ AKGRIVVMPG GGITDKNLQR ILEGSGATEF HCSARSSRDS GMKFRNSSVA
MGASLAHSEY SLKVTDVTKV RTLNAIAKDV LV
