CUTC_SHIFL
ID CUTC_SHIFL Reviewed; 248 AA.
AC P67825; P46719; P76294;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=PF03932 family protein CutC {ECO:0000255|HAMAP-Rule:MF_00795};
GN Name=cutC {ECO:0000255|HAMAP-Rule:MF_00795};
GN Synonyms=cutCm {ECO:0000303|PubMed:15624211};
GN OrderedLocusNames=SF1915, S2005;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
RN [3] {ECO:0007744|PDB:1TWD}
RP X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).
RC STRAIN=301 / Serotype 2a;
RA Forouhar F., Lee I., Vorobiev S.M., Ma L.-C., Shastry R., Conover K.,
RA Xiao R., Acton T.B., Montelione G.T., Tong L., Hunt J.F.;
RT "Crystal Structure of the Putative Copper Homeostasis Protein (CutC) from
RT Shigella flexneri, Northeast Structural Genomics Target SfR33.";
RL Submitted (JUN-2004) to the PDB data bank.
RN [4] {ECO:0007744|PDB:1X7I, ECO:0007744|PDB:1X8C}
RP X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS), AND SUBUNIT.
RX PubMed=15624211; DOI=10.1002/prot.20362;
RA Zhu D.Y., Zhu Y.Q., Huang R.H., Xiang Y., Yang N., Lu H.X., Li G.P.,
RA Jin Q., Wang D.C.;
RT "Crystal structure of the copper homeostasis protein (CutCm) from Shigella
RT flexneri at 1.7 A resolution: the first structure of a new sequence family
RT of TIM barrels.";
RL Proteins 58:764-768(2005).
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00795,
CC ECO:0000305|PubMed:15624211}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00795}.
CC -!- SIMILARITY: Belongs to the CutC family. {ECO:0000255|HAMAP-
CC Rule:MF_00795}.
CC -!- CAUTION: Once thought to be involved in copper homeostasis, experiments
CC in E.coli have shown this is not the case. {ECO:0000255|HAMAP-
CC Rule:MF_00795}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN43469.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAP17302.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE005674; AAN43469.2; ALT_INIT; Genomic_DNA.
DR EMBL; AE014073; AAP17302.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_001185741.1; NZ_WPGW01000115.1.
DR PDB; 1TWD; X-ray; 1.70 A; A/B=1-248.
DR PDB; 1X7I; X-ray; 1.70 A; A/B=1-248.
DR PDB; 1X8C; X-ray; 2.10 A; A/B=1-248.
DR PDBsum; 1TWD; -.
DR PDBsum; 1X7I; -.
DR PDBsum; 1X8C; -.
DR AlphaFoldDB; P67825; -.
DR SMR; P67825; -.
DR STRING; 198214.SF1915; -.
DR EnsemblBacteria; AAN43469; AAN43469; SF1915.
DR EnsemblBacteria; AAP17302; AAP17302; S2005.
DR GeneID; 58391884; -.
DR KEGG; sfx:S2005; -.
DR PATRIC; fig|623.156.peg.3983; -.
DR HOGENOM; CLU_1774599_0_0_6; -.
DR OrthoDB; 1728422at2; -.
DR EvolutionaryTrace; P67825; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.20.20.380; -; 1.
DR HAMAP; MF_00795; CutC; 1.
DR InterPro; IPR005627; Cu_homeostasis_CutC.
DR InterPro; IPR036822; CutC_dom_sf.
DR PANTHER; PTHR12598; PTHR12598; 1.
DR Pfam; PF03932; CutC; 1.
DR SUPFAM; SSF110395; SSF110395; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome.
FT CHAIN 1..248
FT /note="PF03932 family protein CutC"
FT /id="PRO_0000215076"
FT STRAND 3..10
FT /evidence="ECO:0007829|PDB:1TWD"
FT HELIX 11..19
FT /evidence="ECO:0007829|PDB:1TWD"
FT STRAND 23..27
FT /evidence="ECO:0007829|PDB:1TWD"
FT HELIX 31..33
FT /evidence="ECO:0007829|PDB:1TWD"
FT HELIX 40..49
FT /evidence="ECO:0007829|PDB:1TWD"
FT STRAND 54..57
FT /evidence="ECO:0007829|PDB:1TWD"
FT STRAND 60..63
FT /evidence="ECO:0007829|PDB:1TWD"
FT HELIX 69..84
FT /evidence="ECO:0007829|PDB:1TWD"
FT STRAND 88..92
FT /evidence="ECO:0007829|PDB:1TWD"
FT STRAND 99..101
FT /evidence="ECO:0007829|PDB:1TWD"
FT HELIX 103..113
FT /evidence="ECO:0007829|PDB:1TWD"
FT STRAND 116..120
FT /evidence="ECO:0007829|PDB:1TWD"
FT HELIX 122..126
FT /evidence="ECO:0007829|PDB:1TWD"
FT HELIX 130..140
FT /evidence="ECO:0007829|PDB:1TWD"
FT STRAND 144..147
FT /evidence="ECO:0007829|PDB:1TWD"
FT STRAND 151..153
FT /evidence="ECO:0007829|PDB:1TWD"
FT TURN 154..157
FT /evidence="ECO:0007829|PDB:1TWD"
FT HELIX 158..165
FT /evidence="ECO:0007829|PDB:1TWD"
FT STRAND 167..169
FT /evidence="ECO:0007829|PDB:1TWD"
FT STRAND 172..178
FT /evidence="ECO:0007829|PDB:1TWD"
FT TURN 181..183
FT /evidence="ECO:0007829|PDB:1TWD"
FT HELIX 184..190
FT /evidence="ECO:0007829|PDB:1TWD"
FT STRAND 193..197
FT /evidence="ECO:0007829|PDB:1TWD"
FT STRAND 200..203
FT /evidence="ECO:0007829|PDB:1TWD"
FT STRAND 227..230
FT /evidence="ECO:0007829|PDB:1TWD"
FT HELIX 232..247
FT /evidence="ECO:0007829|PDB:1TWD"
SQ SEQUENCE 248 AA; 26762 MW; 998A55A417A010B2 CRC64;
MALLEICCYS MECALTAQQN GADRVELCAA PKEGGLTPSL GVLKSVRQRV TIPVHPIIRP
RGGDFCYSDG EFAAILEDVR TVRELGFPGL VTGVLDVDGN VDMPRMEKIM AAAGPLAVTF
HRAFDMCANP LYTLNNLAEL GIARVLTSGQ KSDALQGLSK IMELIAHRDA PIIMAGAGVR
AENLHHFLDA GVLEVHSSAG AWQASPMRYR NQGLSMSSDE HADEYSRYIV DGAAVAEMKG
IIERHQAK
