ID   CUTR_STRCO              Reviewed;         217 AA.
AC   P0A4I1; Q03756;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Transcriptional regulatory protein CutR;
DE   AltName: Full=Defective melC1 suppressor protein;
GN   Name=cutR; OrderedLocusNames=SCO5862; ORFNames=SC2E9.03;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Member of the two-component regulatory system CutS/CutR,
CC       involved in the regulation of copper metabolism. CutR suppresses a
CC       defective melC1 gene, encoding a putative copper-transfer gene,
CC       probably by altering copper metabolism (By similarity). {ECO:0000250}.
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DR   EMBL; AL939125; CAA16471.1; -; Genomic_DNA.
DR   PIR; T34814; T34814.
DR   RefSeq; NP_629984.1; NC_003888.3.
DR   RefSeq; WP_003993508.1; NZ_VNID01000007.1.
DR   AlphaFoldDB; P0A4I1; -.
DR   SMR; P0A4I1; -.
DR   STRING; 100226.SCO5862; -.
DR   GeneID; 1101304; -.
DR   KEGG; sco:SCO5862; -.
DR   PATRIC; fig|100226.15.peg.5961; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_1_11; -.
DR   InParanoid; P0A4I1; -.
DR   OMA; MSHPGQL; -.
DR   PhylomeDB; P0A4I1; -.
DR   PRO; PR:P0A4I1; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..217
FT                   /note="Transcriptional regulatory protein CutR"
FT                   /id="PRO_0000081085"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        124..217
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   217 AA;  23915 MW;  DD79143A128057C2 CRC64;
     MRVLVVEDEQ LLADAVATGL RREAMAVDVV YDGAAALERI GVNDYDVVVL DRDLPLVHGD
     DVCRKIVELG MPTRVLMLTA SGDVSDRVEG LEIGADDYLP KPFAFSELIA RVRALGRRTS
     VPLPPVLERA GIKLDPNRRE VFRDGKEVQL APKEFAVLEV LMRSEGAVVS AEQLLEKAWD
     ENTDPFTNVV RVTVMTLRRK LGEPPVIVTV PGSGYRI