ID   CUTR_STRLI              Reviewed;         217 AA.
AC   P0A4I2; Q03756;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Transcriptional regulatory protein CutR;
DE   AltName: Full=Defective melC1 suppressor protein;
GN   Name=cutR;
OS   Streptomyces lividans.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=66 / 1326;
RX   PubMed=1956295; DOI=10.1111/j.1365-2958.1991.tb01892.x;
RA   Tseng H.-C., Chen C.W.;
RT   "A cloned ompR-like gene of Streptomyces lividans 66 suppresses defective
RT   melC1, a putative copper-transfer gene.";
RL   Mol. Microbiol. 5:1187-1196(1991).
CC   -!- FUNCTION: Member of the two-component regulatory system CutS/CutR,
CC       involved in the regulation of copper metabolism. CutR suppresses a
CC       defective melC1 gene, encoding a putative copper-transfer gene,
CC       probably by altering copper metabolism.
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DR   EMBL; X58793; CAA41599.1; -; Genomic_DNA.
DR   PIR; S15274; S15274.
DR   AlphaFoldDB; P0A4I2; -.
DR   SMR; P0A4I2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..217
FT                   /note="Transcriptional regulatory protein CutR"
FT                   /id="PRO_0000081086"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        124..217
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   217 AA;  23915 MW;  DD79143A128057C2 CRC64;
     MRVLVVEDEQ LLADAVATGL RREAMAVDVV YDGAAALERI GVNDYDVVVL DRDLPLVHGD
     DVCRKIVELG MPTRVLMLTA SGDVSDRVEG LEIGADDYLP KPFAFSELIA RVRALGRRTS
     VPLPPVLERA GIKLDPNRRE VFRDGKEVQL APKEFAVLEV LMRSEGAVVS AEQLLEKAWD
     ENTDPFTNVV RVTVMTLRRK LGEPPVIVTV PGSGYRI