ID   CUT_CAEEL               Reviewed;        1273 AA.
AC   Q9BL02;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Homeobox protein cut-like ceh-44;
DE            Short=Homeobox protein 44;
GN   Name=ceh-44; ORFNames=Y54F10AM.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Probable DNA-binding regulatory protein involved in cell-fate
CC       specification. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00374}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=a;
CC         IsoId=Q9BL02-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=Q8IA98-1; Sequence=External;
CC       Name=c;
CC         IsoId=Q8IA98-2; Sequence=External;
CC   -!- MISCELLANEOUS: Asn-1149 may participate in regulating DNA-binding
CC       activity by promoting homo- and heterodimerization.
CC   -!- SIMILARITY: Belongs to the CUT homeobox family. {ECO:0000305}.
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DR   EMBL; FO081806; CCD73822.1; -; Genomic_DNA.
DR   RefSeq; NP_497576.1; NM_065175.5. [Q9BL02-1]
DR   AlphaFoldDB; Q9BL02; -.
DR   SMR; Q9BL02; -.
DR   BioGRID; 40620; 3.
DR   STRING; 6239.Y54F10AM.4a; -.
DR   EPD; Q9BL02; -.
DR   PaxDb; Q9BL02; -.
DR   PeptideAtlas; Q9BL02; -.
DR   EnsemblMetazoa; Y54F10AM.4a.1; Y54F10AM.4a.1; WBGene00000464. [Q9BL02-1]
DR   GeneID; 175372; -.
DR   UCSC; Y54F10AM.4c; c. elegans. [Q9BL02-1]
DR   CTD; 175372; -.
DR   WormBase; Y54F10AM.4a; CE27288; WBGene00000464; ceh-44. [Q9BL02-1]
DR   eggNOG; KOG0963; Eukaryota.
DR   eggNOG; KOG2252; Eukaryota.
DR   GeneTree; ENSGT00940000172657; -.
DR   HOGENOM; CLU_003980_0_0_1; -.
DR   InParanoid; Q9BL02; -.
DR   OrthoDB; 181575at2759; -.
DR   PhylomeDB; Q9BL02; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00000464; Expressed in embryo and 4 other tissues.
DR   ExpressionAtlas; Q9BL02; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.260.40; -; 3.
DR   InterPro; IPR003350; CUT_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   Pfam; PF02376; CUT; 3.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM01109; CUT; 3.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF47413; SSF47413; 3.
DR   PROSITE; PS51042; CUT; 3.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Coiled coil; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..1273
FT                   /note="Homeobox protein cut-like ceh-44"
FT                   /id="PRO_0000202391"
FT   DNA_BIND        591..681
FT                   /note="CUT 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00374"
FT   DNA_BIND        832..919
FT                   /note="CUT 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00374"
FT   DNA_BIND        978..1065
FT                   /note="CUT 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00374"
FT   DNA_BIND        1103..1162
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1069..1100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          101..407
FT                   /evidence="ECO:0000255"
FT   COILED          440..468
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1081..1100
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1273 AA;  143526 MW;  AB4F43B8C12B258D CRC64;
     MEIVSRAWES VDWDRIQTRV EAEVTALGQR QDDSEIRKTR LVEESNAYRG RTNKDSRKVA
     IPLIKAFQSE FDGLLARSTA AENALIDICK SIVSLPDPKS LLKGAEAWKN DAEKTQKAVE
     EREELKRQLI KVNNELEDLR GKDVKVRKLK DKLAKLESEQ DIFIENAVNE VEKKAEQELN
     DRLTELIAEK EKMKEQNEIL EKNMDSLESK NKDIQRKLEI AKQTVEQKDG LENEQLSIAM
     KDLADAKHKI VFLEERVSQL ENEAEKVNES KKAGNIEDIA ALGSVLVQKD DVIQQLTNDI
     KRHEASHVEE LAKWKLAVSA VEKKNKTLIG ELNELKNQLE SRNDYEAIKN ELRLLREIEF
     GDSAEANAES IERLGETVET LDRLLAEKNR RLQNENASLR VANDGFKGDE VMKAIVSGSH
     SRVVETVGKR VGAEEANSYR QKNTDSELIE KIQEAKRNKA VCELKFEDPT INVLTYLKNQ
     KAKEAGKRDA PTPILAAPVT PKHVTKLGTH TITTTALPPR TQTAETTQSI LQRLSNGSNK
     HLLNEDLKLS TVLNLKRFSG NPAKPLEAKT SEEQKAELET IEKMQKRIQV NVQALNGHPL
     NTTEIASHCK RLMIAYNIGQ RLFAKHVMNQ VVKSQGSLSE LLSKPRHWNK LTDKGREAFR
     RIYGWISDDE AINLLCSLSP RRVWPADQNI EHPKAETLLD TSDPMEFKEE PVIRYDVTPK
     VEPVIEKIKS PVESPCSSQA GASSLRASRW RHDDISKEKI LSILQTELKK IEEETTESKV
     VVPVKPTATG GNRRFSSNST YESSSLTGKS RPSTVELILK QRISTGLQPL TQAQYDAYTV
     LDTDFLVKQI KEFLTMNSIS QRQFGEYILG LSQGSVSDLL ARPKTWAQLT QKGREPFIRM
     QLFMDDVEAS EENDEKQPKI TICDEDSDLA KTLATLLNAV HREPSEPKTS VKLEPLSEID
     VIMQVPSASK PSSVVKSIDE SSGEEILDTF EIVYQVKGIL EENGISPRVF GDEYLHCTSS
     MCADLMIRTK SFENSKASEK LMYTRMKTFL SDPIAIPLLV EKEESKETVK AKIESVPAPR
     EAPRPVKRKH SSDTDDYDLN TKKPIQRTVI TDYQKDTLRF VFVNEQHPSN ELCEQISLKL
     DMSLRTVQNW FHNHRTRSKA REKEGKVYSD ALPNGTAVKS LTWKDDLQKM LDEAPAITSQ
     WAPDYQNRAG SVKSSTSADS PTNNNYSSPI FSFDKASTTS TVKKPSSTGK LDNLVARMIR
     LAEGREAAAA KAS