ID   CUX2_CONCL              Reviewed;          31 AA.
AC   P0DJB4;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Conotoxin Cltx-2 {ECO:0000303|PubMed:20363338};
DE   AltName: Full=CalTx-2 {ECO:0000305};
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   PROTEIN SEQUENCE, AND HYDROXYLATION AT PRO-6 AND PRO-31.
RC   TISSUE=Venom;
RX   PubMed=20363338; DOI=10.1016/j.ympev.2010.03.029;
RA   Biggs J.S., Watkins M., Puillandre N., Ownby J.P., Lopez-Vera E.,
RA   Christensen S., Moreno K.J., Bernaldez J., Licea-Navarro A., Corneli P.S.,
RA   Olivera B.M.;
RT   "Evolution of Conus peptide toxins: analysis of Conus californicus Reeve,
RT   1844.";
RL   Mol. Phylogenet. Evol. 56:1-12(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is C-C-C-CC-C.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P0DJB4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydroxylation; Neurotoxin;
KW   Secreted; Toxin.
FT   PEPTIDE         1..31
FT                   /note="Conotoxin Cltx-2"
FT                   /id="PRO_0000415050"
FT   MOD_RES         6
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000305|PubMed:20363338"
FT   MOD_RES         31
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000305|PubMed:20363338"
SQ   SEQUENCE   31 AA;  3538 MW;  73FCC2B661FCCD8A CRC64;
     SLCDKPHHNC IDGQTCYHTC CQNGLKCVRY P