CV015_HUMAN
ID CV015_HUMAN Reviewed; 148 AA.
AC Q8WYQ4; Q6ICJ7;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Uncharacterized protein C22orf15;
DE AltName: Full=Protein N27C7-3;
GN Name=C22orf15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RA Shimizu N., Minosima S., Kawasaki K., Sasaki T., Hosono K.;
RT "Molecular cloning of N27C7-3 gene.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
CC -!- INTERACTION:
CC Q8WYQ4-2; Q8IZP0-5: ABI1; NbExp=3; IntAct=EBI-12030460, EBI-11743294;
CC Q8WYQ4-2; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-12030460, EBI-11524452;
CC Q8WYQ4-2; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-12030460, EBI-11977221;
CC Q8WYQ4-2; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-12030460, EBI-10242151;
CC Q8WYQ4-2; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-12030460, EBI-5916454;
CC Q8WYQ4-2; P17066: HSPA6; NbExp=3; IntAct=EBI-12030460, EBI-355106;
CC Q8WYQ4-2; Q9UBY9: HSPB7; NbExp=6; IntAct=EBI-12030460, EBI-739361;
CC Q8WYQ4-2; Q4G0X4: KCTD21; NbExp=3; IntAct=EBI-12030460, EBI-11976683;
CC Q8WYQ4-2; P53667: LIMK1; NbExp=3; IntAct=EBI-12030460, EBI-444403;
CC Q8WYQ4-2; P62487: POLR2G; NbExp=3; IntAct=EBI-12030460, EBI-347928;
CC Q8WYQ4-2; Q12933: TRAF2; NbExp=3; IntAct=EBI-12030460, EBI-355744;
CC Q8WYQ4-2; P36508: ZNF76; NbExp=3; IntAct=EBI-12030460, EBI-7254550;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WYQ4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WYQ4-2; Sequence=VSP_014462, VSP_014463;
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DR EMBL; AB050773; BAB83035.1; -; Genomic_DNA.
DR EMBL; CR456371; CAG30257.1; -; mRNA.
DR EMBL; AP000348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP000349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS13814.2; -. [Q8WYQ4-1]
DR RefSeq; NP_872326.2; NM_182520.2. [Q8WYQ4-1]
DR AlphaFoldDB; Q8WYQ4; -.
DR BioGRID; 127274; 168.
DR IntAct; Q8WYQ4; 12.
DR STRING; 9606.ENSP00000384965; -.
DR BioMuta; C22orf15; -.
DR DMDM; 68565600; -.
DR MassIVE; Q8WYQ4; -.
DR PaxDb; Q8WYQ4; -.
DR PeptideAtlas; Q8WYQ4; -.
DR PRIDE; Q8WYQ4; -.
DR Antibodypedia; 9378; 47 antibodies from 8 providers.
DR DNASU; 150248; -.
DR Ensembl; ENST00000382821.3; ENSP00000372271.3; ENSG00000169314.15. [Q8WYQ4-2]
DR Ensembl; ENST00000402217.8; ENSP00000384965.4; ENSG00000169314.15. [Q8WYQ4-1]
DR GeneID; 150248; -.
DR KEGG; hsa:150248; -.
DR MANE-Select; ENST00000402217.8; ENSP00000384965.4; NM_182520.3; NP_872326.2.
DR UCSC; uc002zxu.4; human. [Q8WYQ4-1]
DR CTD; 150248; -.
DR DisGeNET; 150248; -.
DR GeneCards; C22orf15; -.
DR HGNC; HGNC:15558; C22orf15.
DR HPA; ENSG00000169314; Tissue enriched (fallopian).
DR neXtProt; NX_Q8WYQ4; -.
DR OpenTargets; ENSG00000169314; -.
DR PharmGKB; PA134933953; -.
DR VEuPathDB; HostDB:ENSG00000169314; -.
DR eggNOG; ENOG502S8RG; Eukaryota.
DR GeneTree; ENSGT00390000015147; -.
DR HOGENOM; CLU_132837_2_0_1; -.
DR InParanoid; Q8WYQ4; -.
DR OMA; KRMGTRR; -.
DR OrthoDB; 1575557at2759; -.
DR PhylomeDB; Q8WYQ4; -.
DR TreeFam; TF328811; -.
DR PathwayCommons; Q8WYQ4; -.
DR SignaLink; Q8WYQ4; -.
DR BioGRID-ORCS; 150248; 6 hits in 1052 CRISPR screens.
DR ChiTaRS; C22orf15; human.
DR GenomeRNAi; 150248; -.
DR Pharos; Q8WYQ4; Tdark.
DR PRO; PR:Q8WYQ4; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q8WYQ4; protein.
DR Bgee; ENSG00000169314; Expressed in right uterine tube and 93 other tissues.
DR ExpressionAtlas; Q8WYQ4; baseline and differential.
DR InterPro; IPR039471; CXorf65-like.
DR PANTHER; PTHR33887; PTHR33887; 1.
DR Pfam; PF15874; Il2rg; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..148
FT /note="Uncharacterized protein C22orf15"
FT /id="PRO_0000079576"
FT REGION 122..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 84
FT /note="K -> SKVAQE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15461802"
FT /id="VSP_014462"
FT VAR_SEQ 109..148
FT /note="EELRRLSGLSSVGHNWRKRMGTRRGRHEQSPTSRPRKGPD -> GANRQQPS
FT RTPLAESGIAEKLHQQEGQGP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15461802"
FT /id="VSP_014463"
SQ SEQUENCE 148 AA; 16487 MW; 6DDF102E8B3DAC47 CRC64;
MFIKVMFGAG CSVLVNTSCR LVNLTAHLRQ KAGLPPDATI ALLAEDGNLV SLEEDLKEGA
SRAQTMGNSL LKERAIYVLV RIIKGEDMAS TRYESLLENL DDHYPELAEE LRRLSGLSSV
GHNWRKRMGT RRGRHEQSPT SRPRKGPD
